Kim Yong Soon, Baek Min Won, Sung Jae Hyuck, Ryu Hyun Youl, Kim Jin Sik, Cho Hyun Sun, Choi Byung Gil, Song Min Sub, Song Moon Yong, Baik Eun Ju, Choi Young Kuk, Kim Jong Kyu, Yu Il Je, Song Kyung Seuk
Department of Toxicopathology, Korea Environment & Merchandise Testing Institute, Songdo-dong 7-44, Yeonsu-gu, Incheon, 406-840 Korea.
24Korea Occupational Safety and Health Agency, Daejeon, 305-380 Korea.
Toxicol Res. 2009 Sep;25(3):132-139. doi: 10.5487/TR.2009.25.3.132. Epub 2009 Sep 1.
The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 mg/kg body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 mg/kg body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 mg/kg body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.
为建立国家化学品管理体系并与全球统一分类系统（GHS）类别相匹配，根据单剂量急性经口毒性研究（经合组织准则423）和90天重复剂量亚慢性经口毒性研究准则（经合组织准则408），对过硫酸铵进行了毒性试验，以确定其潜在毒性作用。在急性经口毒性研究中，在第一次和第二次染毒（300毫克/千克体重）后观察到糊状粪便、会阴污染和体重暂时下降。在第三次染毒（2000毫克/千克体重）后，所有试验动物在6小时内死亡。因此，受试物质的GHS类别被认为是4类。在亚慢性毒性研究中，给药组（5、20、80毫克/千克体重）和对照组（仅赋形剂）动物之间的体重变化、食物消耗、血液学、生化和病理学检查均未显示任何明显和显著差异。基于这些结果，未观察到有害作用水平（NOAEL）被认为高于80毫克/千克体重。
