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西西伯利亚人群的复杂医学遗传学研究。IV. 数量性状与多态单基因性状相互关系的多变量统计分析

[Complex medico-genetic study of the populations of western Siberia. IV. A multivariate statistical analysis of the interrelation of quantitative and polymorphic monogenic traits].

作者信息

Puzyrev V P, Lemza S V, Nazarenko S A

出版信息

Genetika. 1988 Aug;24(8):1478-87.

PMID:3203887
Abstract

Multidimensional statistical analysis for a set of morpho- and physiological traits (anthropological, hemodynamic and biochemical) was done by the principal components method with interpretation of the latter. Special features of phenotype relationships were established for some traits of pathogenetic values for human chronic pathology. Heterogeneity of distributions of genotype frequencies for polymorphic traits and chromosome Q segments in histogramms of principal components was shown. The distributions are considered to be of nonrandom patterns and reflect common population genetics processes affecting both classes of traits under study.

摘要

通过主成分分析法对一组形态学和生理学特征(人类学、血液动力学和生物化学特征)进行了多维统计分析,并对结果进行了解释。针对人类慢性病理学中一些具有致病价值的特征,确定了表型关系的特殊特征。在主成分直方图中显示了多态性特征和染色体Q段的基因型频率分布的异质性。这些分布被认为是非随机模式,反映了影响所研究的两类特征的常见群体遗传学过程。

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