Mahgoub Nasrin, Alqadasi Basema, Aldhorae Khalid, Assiry Ali, Altawili Zainb M
Department of General Dentistry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Orthodontic Department Hospital of Stomatology Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
J Int Soc Prev Community Dent. 2019 Nov 13;9(6):542-552. doi: 10.4103/jispcd.JISPCD_249_19. eCollection 2019 Nov-Dec.
iRoot BP Plus, also known as EndoSequence root repair material (EERM) is a premixed bioceramic thick/putty. According to its instruction manual, iRoot BP Plus is composed of tricalcium silicate, zirconium oxide, tantalum pentoxide, dicalcium silicate, calcium sulfate, calcium phosphate monobasic, and filler agents. This systematic review was carried out to evaluate and present the iRoot BP Plus material as a pulp-capping agent.
A systematic search for articles with the scope of the selection criteria undergoing for data extraction was conducted through electronic databases. Studies on evaluation of the cytotoxicity, bioactivity, and dentinal bridge formation of iRoot BP, iRoot BP Plus, ERRM putty, or ERRM paste (ERRM) on variant human cells were selected for models, and dentinal bridge formation on human and animals teeth for in vivo models were selected.
A total of 22 articles were discussed in the review, 14 studies, five studies, and three articles with both studies. Methyl thiazol tetrazolium was the most used method for evaluating cytotoxicity. As for dentinal bridge formation, histological assessment and micro-Computed tomography were used. Human dental pulp cells (hDPCs) were the most investigated for models and rats for models. Except for one study, all studies involved in this review were primarily examining the material and comparing it to different types of mineral trioxide aggregate.
iRoot BP, iRoot BP Plus, and ERRM are biocompatible materials that enhance hDPCs and other variant human cells proliferation, migration, attachment adhesion, mineralization, and dentinal bridge formation.
iRoot BP Plus，也被称为EndoSequence牙根修复材料（EERM），是一种预混的生物陶瓷糊剂/膏剂。根据其产品说明书，iRoot BP Plus由硅酸三钙、氧化锆、五氧化二钽、硅酸二钙、硫酸钙、磷酸二氢钙和填充剂组成。本系统评价旨在评估并介绍iRoot BP Plus材料作为一种盖髓剂的情况。
通过电子数据库对符合数据提取选择标准范围内的文章进行系统检索。选择关于iRoot BP、iRoot BP Plus、ERRM糊剂或ERRM膏剂（ERRM）对不同人类细胞的细胞毒性、生物活性和牙本质桥形成评估的研究用于体外模型，选择关于在人和动物牙齿上牙本质桥形成的研究用于体内模型。
本评价共讨论了22篇文章（14项体外研究、5项体内研究以及3篇同时包含体外和体内研究的文章）。噻唑蓝是评估细胞毒性最常用的方法。至于牙本质桥形成，采用了组织学评估和显微计算机断层扫描。体外模型中对人牙髓细胞（hDPCs）研究最多，体内模型中对大鼠研究最多。除一项研究外，本评价中涉及的所有研究主要是检验该材料并将其与不同类型的三氧化矿物凝聚体进行比较。
iRoot BP、iRoot BP Plus和ERRM是生物相容性材料，可促进hDPCs和其他不同人类细胞的增殖、迁移、附着黏附、矿化以及牙本质桥形成。
