Wang S, Peng C F, Liu H
Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Research Center of Engineering and Technology for Computerized Dentistry & NMPA Key Laboratory for Dental Materials, Beijing 100081, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2022 Dec 18;54(6):1196-1201. doi: 10.19723/j.issn.1671-167X.2022.06.023.
To evaluate the efficacy of iRoot BP Plus, a novel bioceramic material, and mineral trioxide aggregate (MTA) by comparing the clinical and radiographic results of pulpotomy in human primary molars, and to find out the influence factor.
Children who had at least one primary molar diagnosed as pulpitis, and received pulpotomy in the Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology from January, 2017 to December, 2018 were searched by the selection criteria in the Electronic Medical Record Database of Peking University School and Hospital of Stomatology. The molars with the pulp capping agents were iRoot BP Plus or MTA were included, and the molars with other pulp capping agents were excluded. Molars using iRoot BP Plus were selected into the experimental group (iRoot BP Plus group). Molars using MTA were selected into the control group (MTA group) using propensity score matching model (1 ∶ 1), considering the gender, age, tooth position, the title of clinician, pulp status, restoration and length of follow-up as the potential influence factor. Basic information, the relevant medical records including symptoms, clinical and radiographic examination before and after operation, intraoperative information and follow up examination records were collected. The success rates were compared and the influence factors were analyzed respectively.
The study included 132 children, 178 molars (89 molars from each group) and the mean follow-up time was (462±99) days by December, 2019. In the iRoot BP Plus group, 9 molars failed whilst 6 molars failed in MTA group. The success rate was 89.9% and 93.3%, respectively, showing no significant difference between the two groups. Through Cox proportional risk model analysis, the success rate of iRoot BP Plus was significantly lower when the pulp status was poor, while other factors including age, tooth position, title of clinician and restoration were not found to be associated with the clinical outcome.
Pulpotomy of human primary molars with iRoot BP Plus has the same effectiveness with MTA. The pulp status is the main factor that influences the outcome of iRoot BP Plus. Further studies with larger sample sizes and longer follow-up terms are needed.
通过比较iRoot BP Plus（一种新型生物陶瓷材料）和矿物三氧化物凝聚体（MTA）用于人类乳磨牙牙髓切断术的临床和影像学结果，评估其疗效，并找出影响因素。
通过北京大学口腔医院电子病历数据库中的入选标准，搜索2017年1月至2018年12月期间在北京大学口腔医院儿童口腔科诊断为牙髓炎并接受牙髓切断术的至少有一颗乳磨牙的儿童。纳入使用iRoot BP Plus或MTA作为牙髓盖髓剂的磨牙，排除使用其他牙髓盖髓剂的磨牙。使用iRoot BP Plus的磨牙被选入实验组（iRoot BP Plus组）。使用MTA的磨牙使用倾向评分匹配模型（1∶1）选入对照组（MTA组），将性别、年龄、牙位、临床医生职称、牙髓状况、修复情况和随访时间作为潜在影响因素。收集基本信息、相关病历，包括症状、手术前后的临床和影像学检查、术中信息及随访检查记录。比较成功率并分别分析影响因素。
截至2019年12月，该研究纳入132名儿童，178颗磨牙（每组89颗），平均随访时间为（462±9）天。iRoot BP Plus组有9颗磨牙失败，MTA组有6颗磨牙失败。成功率分别为89.9%和93.3%，两组之间无显著差异。通过Cox比例风险模型分析，当牙髓状况较差时，iRoot BP Plus的成功率显著较低，而年龄、牙位、临床医生职称和修复情况等其他因素与临床结果无关。
iRoot BP Plus用于人类乳磨牙牙髓切断术与MTA具有相同的有效性。牙髓状况是影响iRoot BP Plus治疗结果的主要因素。需要进行更大样本量和更长随访期的进一步研究。
