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硼中子俘获治疗中浓度、模体尺寸和肿瘤位置对剂量增强及中子能谱的影响

B Concentration, Phantom Size and Tumor Location Dependent Dose Enhancement and Neutron Spectra in Boron Neutron Capture Therapy.

作者信息

Izadi Vasafi Gh, Firoozabadi M M

机构信息

PhD, Department of Physics, Faculty of Sciences, University of Birjand, Birjand, Iran.

出版信息

J Biomed Phys Eng. 2019 Dec 1;9(6):653-660. doi: 10.31661/jbpe.v0i0.799. eCollection 2019 Dec.

DOI:10.31661/jbpe.v0i0.799
PMID:32039096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6943846/
Abstract

BACKGROUND

The amount of average dose enhancement in tumor loaded with B may vary due to various factors in boron neutron capture therapy.

OBJECTIVE

This study aims to evaluate dose enhancement in tumor loaded with B under influence of various factors and investigate the dependence of this dose enhancement on neutron spectra changes.

MATERIAL AND METHODS

In this simulation study, using Cf as a neutron source, the average in-tumor dose enhancement factor (DEF) and neutron energy spectra were calculated for various B concentrations, phantom with different sizes and for different tumor locations, through MCNPX code.

RESULTS

Obtained results showed that the values of average DEF rise with increasing B concentration, phantom diameter (˂ 30 cm) and tumor distance from the source, but this increment is not linear.

CONCLUSION

It was concluded that inequality in average dose enhancement rates, in tumor loaded with B under influence of various factors in boron neutron capture therapy, is due to non-identical changes of both the thermal neutron flux with increasing same number of B atoms and same thickness of scattering material, and the thermal to fast neutron flux ratio with increasing equal distances of tumor from the source.

摘要

背景

在硼中子俘获治疗中，含硼肿瘤内的平均剂量增强量可能因多种因素而有所不同。

目的

本研究旨在评估多种因素影响下含硼肿瘤的剂量增强情况，并研究这种剂量增强对中子能谱变化的依赖性。

材料与方法

在本模拟研究中，以Cf作为中子源，通过MCNPX程序，针对不同的硼浓度、不同尺寸的模体以及不同的肿瘤位置，计算肿瘤内平均剂量增强因子（DEF）和中子能谱。

结果

所得结果表明，平均DEF值随硼浓度、模体直径（˂ 30 cm）以及肿瘤与源的距离增加而升高，但这种增加并非呈线性关系。

结论

得出的结论是，在硼中子俘获治疗中多种因素影响下，含硼肿瘤内平均剂量增强率存在差异，这是由于随着相同数量的硼原子和相同厚度的散射材料增加，热中子通量的变化不同，以及随着肿瘤与源的距离等距增加，热中子与快中子通量比的变化不同所致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6750/6943846/0783d851f7b3/JBPE-9-653-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6750/6943846/d9d59a8d5e0f/JBPE-9-653-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6750/6943846/5ed2cdd68850/JBPE-9-653-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6750/6943846/209b3f760cd1/JBPE-9-653-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6750/6943846/b3ef3101dbb7/JBPE-9-653-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6750/6943846/9d637fffb084/JBPE-9-653-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6750/6943846/0783d851f7b3/JBPE-9-653-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6750/6943846/d9d59a8d5e0f/JBPE-9-653-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6750/6943846/5ed2cdd68850/JBPE-9-653-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6750/6943846/209b3f760cd1/JBPE-9-653-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6750/6943846/b3ef3101dbb7/JBPE-9-653-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6750/6943846/9d637fffb084/JBPE-9-653-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6750/6943846/0783d851f7b3/JBPE-9-653-g006.jpg

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