Bergmann K C, Waldman R H
Karl-Hansen-Klinik, Bad Lippspringe, FRG.
Int Arch Allergy Appl Immunol. 1988;87(3):334-5. doi: 10.1159/000234695.
The adjuvant activity of avridine, a synthetic lipoidal amine, incorporated in liposomes, was studied in mice immunized orally with killed influenza virus vaccine (A/PR/8/34, H1N1). Coadministration of avridine-containing liposomes and viral antigen enhanced the remote-site IgA antibody response in the respiratory tract without a concomitant serum antibody response or side effects. The results support the possible use of mucosal adjuvants for oral immunization against respiratory pathogens.
研究了包裹在脂质体中的合成类脂胺阿弗立定（avridine）的佐剂活性，该研究以经口接种灭活流感病毒疫苗（A/PR/8/34，H1N1）的小鼠为对象。含阿弗立定的脂质体与病毒抗原共同给药可增强呼吸道远端部位的IgA抗体反应，而不会伴随血清抗体反应或产生副作用。这些结果支持了黏膜佐剂可能用于针对呼吸道病原体进行口服免疫的观点。
