带正电荷的脂质体阿弗立定佐剂增强火鸡对三价禽流感疫苗的抗体反应。

Enhancement of antibody response of turkeys to trivalent avian influenza vaccine by positively charged liposomal avridine adjuvant.

作者信息

Fatunmbi O O, Newman J A, Sivanandan V, Halvorson D A

机构信息

Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul 55108.

出版信息

Vaccine. 1992;10(9):623-6. doi: 10.1016/0264-410x(92)90444-o.

DOI:10.1016/0264-410x(92)90444-o

PMID:1502840

Abstract

Trivalent avian influenza (AIV) antigens (H4N8, H5N2 and H7N3), mixed with positively charged, negatively charged and neutral avridine-containing liposomes, and oil-emulsion were subcutaneously administered to 6-week-old turkeys. Charged liposomal avridine adjuvant, either positive or negative, produced a better antibody response than uncharged liposomal avridine or oil-emulsion adjuvants when used in a trivalent avian influenza vaccine. The antibody response to the different antigens was generally greater to the positively charged adjuvanted vaccine compared with the negatively or neutral charged or oil-emulsion adjuvanted vaccines and these differences were significant (P less than 0.05) with the three antigens. The results suggest that the positively charged liposomal avridine plays a significant role as adjuvant to the AIV antigens.

摘要

将三价禽流感（AIV）抗原（H4N8、H5N2和H7N3）与带正电荷、负电荷和中性的含吖啶脂质体以及油乳剂混合，皮下接种6周龄火鸡。当用于三价禽流感疫苗时，带电荷的脂质体吖啶佐剂，无论是正电荷还是负电荷，都比不带电荷的脂质体吖啶或油乳剂佐剂产生更好的抗体反应。与带负电荷、中性电荷或油乳剂佐剂的疫苗相比，对不同抗原的抗体反应通常对带正电荷佐剂的疫苗更大，并且对于这三种抗原，这些差异具有显著性（P小于0.05）。结果表明，带正电荷的脂质体吖啶作为AIV抗原的佐剂发挥了重要作用。