Fatunmbi O O, Newman J A, Sivanandan V, Halvorson D A
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul 55108.
Vaccine. 1992;10(9):623-6. doi: 10.1016/0264-410x(92)90444-o.
Trivalent avian influenza (AIV) antigens (H4N8, H5N2 and H7N3), mixed with positively charged, negatively charged and neutral avridine-containing liposomes, and oil-emulsion were subcutaneously administered to 6-week-old turkeys. Charged liposomal avridine adjuvant, either positive or negative, produced a better antibody response than uncharged liposomal avridine or oil-emulsion adjuvants when used in a trivalent avian influenza vaccine. The antibody response to the different antigens was generally greater to the positively charged adjuvanted vaccine compared with the negatively or neutral charged or oil-emulsion adjuvanted vaccines and these differences were significant (P less than 0.05) with the three antigens. The results suggest that the positively charged liposomal avridine plays a significant role as adjuvant to the AIV antigens.
将三价禽流感（AIV）抗原（H4N8、H5N2和H7N3）与带正电荷、负电荷和中性的含吖啶脂质体以及油乳剂混合，皮下接种6周龄火鸡。当用于三价禽流感疫苗时，带电荷的脂质体吖啶佐剂，无论是正电荷还是负电荷，都比不带电荷的脂质体吖啶或油乳剂佐剂产生更好的抗体反应。与带负电荷、中性电荷或油乳剂佐剂的疫苗相比，对不同抗原的抗体反应通常对带正电荷佐剂的疫苗更大，并且对于这三种抗原，这些差异具有显著性（P小于0.05）。结果表明，带正电荷的脂质体吖啶作为AIV抗原的佐剂发挥了重要作用。
