Hager J, Brandstaetter F, Koller I, Unger F
Surgical Clinic I, University of Innsbruck, Austria.
Int J Artif Organs. 1988 Nov;11(6):465-8.
The spindle pump--a new attempt at assisted circulation--was developed to prevent the main problems of nonpulsatile blood pumps, i.e. traumatic hemolysis, thrombus formation and sealing. It was essential to achieve adequate output with the lowest possible speed in order to minimize traumatic hemolysis. The result was a spindle pump with three windings in a U-shaped housing driven by an electric motor. Many tests were necessary to establish a prototype. The spindle was completely redesigned several times to reach an acceptable volume output and corresponding pressure output. In animal experiments this final prototype working as a LVAD, with a speed of 5400 RPM circulates 4 liters/min against BP of 110 mmHg. The hemolysis rate has been low in acute and survival experiments (27 hours up to now), and is between 25 and 30 mg/100 ml of free hemoglobin, thus within the normal range.
纺锤形泵——辅助循环的一项新尝试——旨在解决非搏动性血泵的主要问题，即创伤性溶血、血栓形成和密封问题。为了将创伤性溶血降至最低，以尽可能低的速度实现足够的输出至关重要。最终设计出了一种在U形外壳中有三个绕组、由电动马达驱动的纺锤形泵。制造一个原型需要进行多次测试。纺锤体经过了几次彻底重新设计，以达到可接受的容积输出和相应的压力输出。在动物实验中，这个最终的原型作为左心室辅助装置工作，转速为5400转/分钟时，能以110毫米汞柱的血压每分钟循环4升血液。在急性实验和存活实验（至今长达27小时）中，溶血率一直很低，游离血红蛋白在25至30毫克/100毫升之间，因此处于正常范围内。
