Hager J, Klima G, Koller J, Fitz A, Mayr A, Brandstaetter F
Klinische Abteilung für Allgemeine Chirurgie, University of Innsbruck, Innsbruck, Austria.
Artif Organs. 2002 Jan;26(1):62-7. doi: 10.1046/j.1525-1594.2002.6791_4.x.
According to recent trends to develop implantable nonpulsatile blood pumps for different function modes and times, our intention was and still is to build a Mini-Spindle-Pump for a pumping duration of about 14 days. Initial conception for this plan was the premise that the device in a mock circuit should move 4 L of water/min at a speed of 12,000 to 15,000 rpm against a pressure difference of 90 mm Hg between pump inlet and outlet. Despite the development of 6 different prototypes, this project was not realized. Under the above-mentioned conditions, the main problem of this type of blood pump, the blood trauma, could not be reduced to an adequate level, i.e., the Mini-Spindle-Pump is not a high speed pump. Therefore, a revision of the conception was necessary. The device in a mock circuit should transport 5 L of water/min at a speed of about 9,000 rpm against a pressure difference of 90 mm Hg between its inlet and outlet. Considering the implantability of the blood pump, the following measurements for its components were arrived at. The U-shaped blockformed plexiglas housing was enlarged to 120 x 40 x 40 mm (length of blood chamber 86 mm, inner diameter 27 mm), and the rotor with 5 windings was redesigned at a length of 64 mm (outer diameter 25 mm, inner diameter 6.7 mm). In a mock circuit, this 7th prototype transported with a speed of 9,000 rpm about 10 L of water/min at an afterload of 80 mm Hg. In acute animal experiments with calves up to 15 h of pumping duration, the device showed the expected efficiency. Experiments with a longer pumping duration are necessary to confirm that this prototype will fulfill the criteria of a short-term pump according to Dr. Y. Nosé's advice.
根据最近开发用于不同功能模式和时长的植入式非搏动性血泵的趋势，我们过去以及现在的目标都是制造一台用于约14天泵送时长的微型轴流泵。该计划的最初设想是，该装置在模拟回路中应以12,000至15,000转/分钟的速度，克服泵进出口之间90毫米汞柱的压差，每分钟输送4升水。尽管开发了6种不同的原型，但该项目并未实现。在上述条件下，这类血泵的主要问题，即血液损伤，无法降低到适当水平，也就是说，微型轴流泵不是高速泵。因此，有必要对设想进行修订。该装置在模拟回路中应以约9,000转/分钟的速度，克服其进出口之间90毫米汞柱的压差，每分钟输送5升水。考虑到血泵的可植入性，得出了其组件的以下尺寸。U形块状有机玻璃外壳扩大到120×40×40毫米（血腔长度86毫米，内径27毫米），带有5个绕组的转子重新设计为长度64毫米（外径25毫米，内径6.7毫米）。在模拟回路中，这个第7个原型以9,000转/分钟的速度在80毫米汞柱的后负荷下每分钟输送约10升水。在对小牛进行的长达15小时泵送时长的急性动物实验中，该装置显示出预期的效率。根据Y. Nosé博士的建议，需要进行更长泵送时长的实验，以确认这个原型是否符合短期泵的标准。
