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男性乳腺囊内乳头状癌:诊断与治疗的困境。

Intracystic papillary carcinoma of the male breast: Dilemmas in diagnosis and management.

机构信息

Department of General Surgery, All India Institute of Medical Sciences, Patna, Bihar, India.

出版信息

Breast Dis. 2020;39(2):105-107. doi: 10.3233/BD-190421.

Abstract

Intracystic papillary carcinoma (IPC) is a rare malignancy of the breast which is usually found in postmenopausal women. It is still rarer in males and may present with signs of a benign cystic lump. It is sub-classified into three equally prevalent groups considering treatment strategies: intracystic papillary carcinoma alone, intracystic papillary carcinoma with ductal carcinoma in-situ, and those with evidence of invasion. Even if a preoperative diagnosis is achieved, there are no specific guidelines for the treatment of IPC. Treatment modalities including the extent of surgical excision, lymph node dissection, radiation, and chemotherapy are determined by the grade and size of the lesion and sub-types. However, several reports and studies showed good prognosis with conservative surgery without axillary dissection in IPC not associated with carcinoma in situ or micro-invasion. We present a 40 years old male patient with IPC who was managed by modified radical mastectomy and adjuvant hormone therapy. A brief review of the literature and clinical characteristics, pathology, and treatment of IPC are discussed.

摘要

囊内乳头状癌(IPC)是一种罕见的乳腺恶性肿瘤,通常发生在绝经后妇女中。在男性中更为罕见,可能表现为良性囊性肿块的征象。根据治疗策略,可将其细分为三组:单纯囊内乳头状癌、囊内乳头状癌伴导管原位癌,以及有浸润证据的癌。即使术前做出诊断,对于 IPC 的治疗也没有具体的指南。治疗方式包括手术切除的范围、淋巴结清扫、放疗和化疗,取决于病变的分级和大小以及亚型。然而,一些报道和研究表明,在不伴有原位癌或微浸润的 IPC 中,保留乳房的手术联合腋窝清扫术具有良好的预后。我们报告了一例 40 岁男性 IPC 患者,采用改良根治性乳房切除术和辅助激素治疗。对 IPC 的文献复习、临床特征、病理学和治疗进行了讨论。

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