Department of Psychiatry.
J Nerv Ment Dis. 2020 Jun;208(6):481-487. doi: 10.1097/NMD.0000000000001151.
The aim of this study was to investigate the factors associated with illness insight and medication adherence in bipolar disorder (BD). This is a cross-sectional study (with a retrospective evaluation of longitudinal variables) and a secondary analysis of a BD database. The insight of 108 outpatients (age, 48.2 ± 14.1 years, 69% women, 33% euthymic) was measured with three items of the Association of Methodology and Documentation in Psychiatry scale. Their adherence was assessed through patients' and caregivers' reports, plus serum levels. We performed multivariate logistic regression analyses. Full insight was independently and directly associated with adherence, a social support score, and depressive symptoms and inversely associated with intensity of manic symptoms, problems ever with alcohol, and age at onset of the first symptoms. Medication adherence was independently and directly associated with insight, being married, and having had a psychiatric hospitalization and inversely with having suffered a high number of depressive episodes, intensity of manic symptoms, and heavy tobacco smoking.
本研究旨在探讨与双相情感障碍（BD）患者疾病认知和药物依从性相关的因素。这是一项横断面研究（对纵向变量进行回顾性评估），也是对 BD 数据库的二次分析。使用精神病学方法和文献协会的三个项目来衡量 108 名门诊患者（年龄 48.2±14.1 岁，69%为女性，33%为病情稳定）的认知情况。通过患者和护理人员的报告以及血清水平来评估其依从性。我们进行了多变量逻辑回归分析。完全认知与依从性、社会支持评分以及抑郁症状呈独立且直接相关，与躁狂症状强度、曾经有过酒精问题以及首次出现症状的年龄呈负相关。药物依从性与认知、已婚以及曾经住院治疗呈独立且直接相关，与抑郁发作次数较多、躁狂症状强度以及重度吸烟呈负相关。
