Alatortseva G I, Lukhverchik L N, Nesterenko L N, Dotsenko V V, Amiantova I I, Mikhailov M I, Kyuregian K K, Malinnikova E Y, Nurmatov Z S, Nurmatov A Z, Tashov K E, Kasymov O T, Zverev V V
Federal State Budgetary Scientific Institution «I.I. Mechnikov Research Institute of Vaccines and Sera», 105064, Moscow, Russia.
Russian Medical Academy of Postgraduate Education of the Ministry of Healthcare of the Russian Federation, 125993, Moscow, Russia.
Klin Lab Diagn. 2019;64(12):740-746. doi: 10.18821/0869-2084-2019-64-12-740-746.
Despite the fact that the Kyrgyz Republic (KR) belongs to the highly endemic regions of the world for hepatitis E, the true extent of the spread of this infection in the country remains poorly understood. It was estimated the prevalence of serological markers of hepatitis E virus (HEV) infection among patients with acute viral hepatitis (AVH) from the regions of the Kyrgyz Republic with a high level of seroprevalence previously established by us. Blood sera samples of hepatitis patients who were admitted to hospitals of Kyrgyzstan in the period 2018-2019 were examined by the enzyme immunoassay method using the kits «DS-ELISA-Anti-HEVIgG» and «DS-ELISA-ANTI-HEV-IgM» (RPC Diagnostic Systems, Russia). IgG and IgM antibodies to HEV were detected in 103 of 344 studied samples (29.9%). Most often, seropositive specimens were detected among people of age groups under 20 and over 40 years old. Hepatitis with the fecal-oral mode of transmission was dominated in the structure of AVH: the specific gravity of hepatitis E was 47.9%, hepatitis A - 35.32%. Markers of mixed infections with other hepatitis viruses have been detected in 40.4% IgM-positive individuals. Thus, high prevalence of serological markers of HEV infection in the territory of Kyrgyzstan during the interepidemic period had been shown. The necessity of including the determination of serological markers of hepatitis E into the algorithm for the comprehensive diagnosis of AVH in patients of all age groups with liver pathology had been confirmed.
尽管吉尔吉斯共和国属于世界上戊型肝炎高度流行地区，但该国这种感染的实际传播程度仍知之甚少。我们根据先前确定的血清阳性率较高的吉尔吉斯共和国各地区急性病毒性肝炎（AVH）患者中戊型肝炎病毒（HEV）感染血清学标志物的流行情况进行了估算。采用俄罗斯RPC诊断系统公司生产的“DS-ELISA-抗HEV IgG”和“DS-ELISA-抗HEV IgM”试剂盒，通过酶免疫测定法对2018 - 2019年期间入住吉尔吉斯斯坦医院的肝炎患者的血清样本进行检测。在344份研究样本中的103份（29.9%）检测到了抗HEV的IgG和IgM抗体。血清阳性样本最常出现在20岁以下和40岁以上年龄组人群中。在AVH的构成中，以粪-口传播方式的肝炎占主导：戊型肝炎的比重为47.9%，甲型肝炎为35.32%。在40.4%的IgM阳性个体中检测到了与其他肝炎病毒混合感染的标志物。因此，已表明吉尔吉斯斯坦境内在流行间期HEV感染血清学标志物的高流行率。已证实有必要将戊型肝炎血清学标志物的检测纳入所有有肝脏病变的各年龄组AVH综合诊断算法中。
