改良格拉斯哥预后评分和癌胚抗原可预测老年结直肠癌患者的不良预后。
Modified Glasgow Prognostic Score and Carcinoembryonic Antigen Predict Poor Prognosis in Elderly Patients with Colorectal Cancer.
机构信息
Department of Surgery, Yokohama Minami Kyosai Hospital, Yokohama, Japan,
Department of Surgery, Yokohama Minami Kyosai Hospital, Yokohama, Japan.
出版信息
Oncol Res Treat. 2020;43(4):125-133. doi: 10.1159/000505930. Epub 2020 Feb 10.
OBJECTIVE
To investigate the prognostic values of the preoperative modified Glasgow Prognostic Score (mGPS) and carcinoembryonic antigen (CEA) alone and combined in elderly patients with colorectal cancer (CRC) planning to receive curative surgery.
METHODS
We retrospectively analyzed 130 elderly patients (aged ≥80 years) with CRC who received curative surgery between 2008 and 2016. The preoperative mGPS and CEA levels were calculated.
RESULTS
Elevated preoperative mGPS or CEA level was significantly associated with shorter relapse-free survival (p = 0.005, both) and cancer-specific survival (p = 0.011 and p < 0.001, respectively). Combined use of these two factors improved the predictive accuracy for tumor recurrence relative to that of either factor.
CONCLUSION
Both mGPS and CEA were independent prognostic factors of CRC in elderly patients receiving curative surgery, but their combination was more accurate.
目的
探讨术前改良格拉斯哥预后评分（mGPS）和癌胚抗原（CEA）单独及联合用于计划接受根治性手术的老年结直肠癌（CRC）患者的预后价值。
方法
我们回顾性分析了 2008 年至 2016 年间接受根治性手术的 130 例老年 CRC 患者（年龄≥80 岁）。计算了术前 mGPS 和 CEA 水平。
结果
术前 mGPS 或 CEA 水平升高与无复发生存期（p = 0.005，均）和癌症特异性生存期（p = 0.011 和 p < 0.001，分别）显著缩短相关。这两个因素的联合使用提高了对肿瘤复发的预测准确性，优于任何单一因素。
结论
mGPS 和 CEA 都是接受根治性手术的老年 CRC 患者的独立预后因素，但两者联合使用更为准确。
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