腹腔镜结直肠癌手术后第7天C反应蛋白与白蛋白比值对预后的临床影响
Clinical impact of C-reactive protein to albumin ratio of the 7th postoperative day on prognosis after laparoscopic colorectal cancer surgery.
作者信息
Kataoka Masahiro, Gomi Kuniyuki, Ichioka Ken, Iguchi Takuya, Shirota Tomoki, Makino Arano, Shimada Ko, Maruyama Kiyotomi, Mihara Motohiro, Kajikawa Shoji
机构信息
Department of Surgery, Suwa Red Cross Hospital, Nagano, Japan.
出版信息
Ann Coloproctol. 2023 Aug;39(4):315-325. doi: 10.3393/ac.2022.00234.0033. Epub 2022 Jun 13.
PURPOSE
C-reactive protein to albumin ratio (CAR) has been utilized as a prognostic factor in various carcinomas. We investigated the relationship between preoperative, postoperative day (POD) 1, and POD 7 CARs and the prognosis of patients with colorectal cancer (CRC).
METHODS
Three hundred twenty patients with CRC who underwent laparoscopic radical resection between May 2011 and December 2016 were enrolled. Patients were selected into 2 groups, high CAR and low CAR (n=72/group), based on preoperative, POD 1, and POD 7 CARs. The relapse-free survival (RFS) and overall survival (OS) were compared between groups using propensity score matching.
RESULTS
The high CAR group had a significantly worse RFS (P<0.001) and OS (P=0.002) at POD 7 than those in the low CAR group. However, in preoperative and POD 1 analysis, no differences were observed.
CONCLUSION
In patients with CRC, CAR of POD 7 was a significant prognostic factor.
目的
C反应蛋白与白蛋白比值（CAR）已被用作多种癌症的预后因素。我们研究了术前、术后第1天（POD 1）和术后第7天（POD 7）的CAR与结直肠癌（CRC）患者预后之间的关系。
方法
纳入2011年5月至2016年12月期间接受腹腔镜根治性切除术的320例CRC患者。根据术前、POD 1和POD 7的CAR将患者分为两组，即高CAR组和低CAR组（每组n = 72）。采用倾向评分匹配法比较两组之间的无复发生存期（RFS）和总生存期（OS）。
结果
在POD 7时，高CAR组的RFS（P < 0.001）和OS（P = 0.002）明显低于低CAR组。然而，在术前和POD 1分析中，未观察到差异。
结论
在CRC患者中，POD 7的CAR是一个重要的预后因素。
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