土耳其某单一中心 9 年经验:腹膜透析患者的长期临床结局。

Long-term clinical outcomes of peritoneal dialysis patients: 9-year experience of a single centre in Turkey.

机构信息

Department of Nephrology, Faculty of Medicine, Başkent University, Adana, Turkey

出版信息

Turk J Med Sci. 2020 Apr 9;50(2):386-397. doi: 10.3906/sag-1909-98.

Abstract

BACKGROUND/AIM: The aim of this study was to evaluate the clinical outcomes and identify the predictors of mortality in peritoneal dialysis patients.

MATERIALS AND METHODS

Medical records of all incident peritoneal dialysis (PD) patients followed up between January 2011 and May 2019 were reviewed retrospectively. All patients were followed up until death, renal transplantation, transfer to haemodialysis or the end of the study.

RESULTS

A total of 242 patients were included in the study. The incidence of peritonitis was 0.18 (ranging from 0 to 14.9) episodes per patient year. Death occurred in 28% (n: 68) of cases. Age, diabetes mellitus, malignancy and refractory heart failure were independent risk factors for all-cause mortality according to multivariate analysis. The presence of comorbid disease and diabetes mellitus and patients aged > 65 years were associated with increased risk of mortality and decreased patient survival. Peritonitis history was associated with increased risk of mortality. Between peritonitis and peritonitis-free group, there was no significant difference in Kaplan-Meier curves in terms of patient survival.

CONCLUSION

This is the first study to define 9-year mortality predictors in PD patients in our centre. Although peritonitis is the most feared complication of PD, our study showed that peritonitis did not reduce patient survival.

摘要

背景/目的:本研究旨在评估腹膜透析患者的临床结局,并确定其死亡率的预测因素。

材料和方法

回顾性分析了 2011 年 1 月至 2019 年 5 月期间接受随访的所有新诊断腹膜透析(PD)患者的病历。所有患者均随访至死亡、肾移植、转为血液透析或研究结束。

结果

本研究共纳入 242 例患者。腹膜炎的发生率为 0.18 例/患者年(0 至 14.9 例)。28%(n:68)的患者死亡。多因素分析显示,年龄、糖尿病、恶性肿瘤和难治性心力衰竭是全因死亡的独立危险因素。合并症和糖尿病以及年龄>65 岁与死亡率增加和患者生存时间缩短相关。腹膜炎病史与死亡率增加相关。在腹膜炎和无腹膜炎组之间,患者生存的 Kaplan-Meier 曲线无显著差异。

结论

这是我们中心首例定义 PD 患者 9 年死亡率预测因素的研究。虽然腹膜炎是 PD 最可怕的并发症,但我们的研究表明腹膜炎不会降低患者的生存率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135c/7164764/3b474ddcebe6/turkjmedsci-50-386-fig001.jpg

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