农村乌干达阿尔茨海默病和相关痴呆的患病率及其相关因素：横断面、基于人群的研究。
Prevalence and correlates of Alzheimer's disease and related dementias in rural Uganda: cross-sectional, population-based study.
机构信息
Mbarara University of Science and Technology, Mbarara, Uganda.
Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
出版信息
BMC Geriatr. 2020 Feb 10;20(1):48. doi: 10.1186/s12877-020-1461-z.
BACKGROUND
There is a paucity of data on the prevalence and correlates of Alzheimer's disease and related dementias in sub-Saharan Africa. The aim of the study was to estimate the prevalence and correlates of Alzheimer's disease and related dementias in rural Uganda.
METHODS
We conducted a cross-sectional, population-based study in a rural region of southwestern Uganda. The Brief Community Screening Instrument for Dementia was administered to a multi-stage area probability sample of 400 people aged 60 years and over. Multivariable logistic regression was used to estimate correlates of probable dementia.
RESULTS
Overall, 80 (20%) of the sample screened positive for dementia. On multivariable regression, we estimated the following correlates of probable dementia: age (adjusted odds ratio [AOR], 1.02 per year; 95% confidence interval [CI], 1.10-1.03, p<0.001), having some formal education (AOR, 0.57; 95% CI, 0.41-0.81, p = 0.001), exercise (AOR, 0.44; 95% CI, 0.27-0.72, p = 0.001), and having a ventilated kitchen (AOR, 0.43; (95% CI, 0.24-0.77, p = 0.001).
CONCLUSIONS
In this population-based sample of older-age adults in rural Uganda, nearly one-fifth screened positive for dementia.
背景
撒哈拉以南非洲地区关于阿尔茨海默病和相关痴呆症的患病率和相关因素的数据很少。本研究旨在估计乌干达农村地区阿尔茨海默病和相关痴呆症的患病率和相关因素。
方法
我们在乌干达西南部的一个农村地区进行了一项横断面、基于人群的研究。对一个多阶段的地区概率样本中的 400 名 60 岁及以上的人进行了简短的社区痴呆症筛查工具测试。多变量逻辑回归用于估计可能痴呆症的相关因素。
结果
总体而言，样本中有 80 人（20%）筛查出患有痴呆症。在多变量回归中，我们估计了以下可能痴呆症的相关因素：年龄（调整后的优势比 [AOR]，每年增加 1.02；95%置信区间 [CI]，1.10-1.03，p<0.001）、有一定的正规教育（AOR，0.57；95% CI，0.41-0.81，p=0.001）、锻炼（AOR，0.44；95% CI，0.27-0.72，p=0.001）和有通风厨房（AOR，0.43；95% CI，0.24-0.77，p=0.001）。
结论
在乌干达农村地区的这一基于人群的老年人群体样本中，近五分之一的人筛查出患有痴呆症。
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