吲哚-2-羧酰胺类化合物与β-内酰胺类抗生素对脓肿分枝杆菌的协同作用。
Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus.
机构信息
Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France.
Department of Pharmaceutical Sciences, College of Pharmacy, Marshall B. Ketchum University, Fullerton, California, USA.
出版信息
Antimicrob Agents Chemother. 2020 Apr 21;64(5). doi: 10.1128/AAC.02548-19.
Abstract
New drugs or therapeutic combinations are urgently needed against Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against We show here that these compounds act synergistically with imipenem and cefoxitin and increase the bactericidal activity of the β-lactams against In addition, compound 12 also displays synergism with imipenem and cefoxitin within infected macrophages. The clinical potential of these new drug combinations requires further evaluation.
摘要
先前，我们已经证明了吲哚-2-甲酰胺 6 和 12 对 有很强的抑制作用。 我们在此表明，这些化合物与亚胺培南和头孢西丁协同作用，并增加了β-内酰胺类抗生素对 的杀菌活性。此外，化合物 12 与感染巨噬细胞中的亚胺培南和头孢西丁也有协同作用。这些新的药物组合的临床潜力需要进一步评估。
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