Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Université Paris Diderot, Paris, France.
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Université Paris Diderot, Paris, France
Antimicrob Agents Chemother. 2019 Mar 27;63(4). doi: 10.1128/AAC.01915-18. Print 2019 Apr.
infections are difficult to treat because of their resistance to many antibiotics. , tedizolid combined with imipenem displayed a moderate synergistic effect (fractional inhibitory concentration index, 0.41) but no bactericidal activity. Intracellularly, tedizolid 2 μg/ml (half of the MIC), corresponding to the peak serum concentration, increased the efficacy of imipenem at 8 and 32 μg/ml. Addition of avibactam and rifabutin, alone or in combination, improved the activity of the imipenem-tedizolid combination.
这些感染很难治疗，因为它们对许多抗生素具有耐药性。替加环素与亚胺培南联合显示出适度的协同作用（抑菌浓度指数，0.41），但没有杀菌活性。在细胞内，替加环素 2μg/ml（MIC 的一半），相当于血清峰浓度，增加了 8μg/ml 和 32μg/ml 亚胺培南的疗效。阿维巴坦和利福布丁单独或联合使用可提高亚胺培南-替加环素联合用药的活性。
