慢性下背痛患者的健康相关生活质量是否下降？一项系统评价和荟萃分析的方案。
Do patients with chronic low-back pain experience a loss of health-related quality of life? A protocol for a systematic review and meta-analysis.
机构信息
Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.
Health Service Management Board, Santa Maria alle Scotte University Hospital, Siena, Italy.
出版信息
BMJ Open. 2020 Feb 9;10(2):e033396. doi: 10.1136/bmjopen-2019-033396.
INTRODUCTION
Health-related quality of life in chronic low back pain (LBP) is an important issue since various individual factors such as perceived loss of autonomy, inability to continue daily life and anxiety can contribute to maintenance or deterioration of this condition. Health-related quality of life is also important because it can predict the probability of recovery or recrudescence over time. In the literature, there is no systematic review on this topic. The present paper describes a protocol of the first systematic review and meta-analysis aimed at summarising the data on health-related quality of life in patients with chronic LBP compared with healthy controls. Gender, age and comorbidity of psychiatric disorders (mood or anxiety disorders) will be explored as moderators. Studies will be included if they used a case-control design comparing adults with chronic LBP to healthy controls on health-related quality of life through validated interviews/questionnaires.
METHODS AND ANALYSIS
According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses, a systematic review and meta-analysis will be conducted from 10th to 17th January 2020. Independent reviewers will search published/unpublished studies through electronic databases (Scopus, PubMed, EMBASE and the Cochrane Library) and additional sources, will extract the data and assess the methodological quality through the Newcastle-Ottawa Scale. Random-effect meta-analysis will be carried out by calculating effect sizes as Cohen's d indices. Publication bias will be assessed and moderators of the effect sizes will be investigated through weighted least squares meta-regression.The knowledge whether health-related quality of life is better or worse as a function of some individual characteristics may suggest personalised care pathways according to a precision medicine approach.
ETHICS AND DISSEMINATION
The current review does not require ethics approval. The results will be disseminated through publications in peer-reviewed journals.
PROSPERO REGISTRATION NUMBER
CRD42019131749.
简介
慢性下背痛（LBP）患者的健康相关生活质量是一个重要问题，因为各种个体因素，如感知到的自主丧失、无法继续日常生活和焦虑，都可能导致这种状况的维持或恶化。健康相关生活质量也很重要，因为它可以预测随着时间的推移恢复或复发的可能性。在文献中，没有关于这个主题的系统评价。本文描述了一项系统评价和荟萃分析的方案，旨在总结慢性 LBP 患者与健康对照组相比健康相关生活质量的数据。性别、年龄和精神障碍（情绪或焦虑障碍）的合并症将作为调节因素进行探讨。如果研究使用病例对照设计，通过经过验证的访谈/问卷将患有慢性 LBP 的成年人与健康对照组进行比较，评估健康相关生活质量，则将纳入研究。
方法和分析
根据系统评价和荟萃分析的首选报告项目，将在 2020 年 1 月 10 日至 17 日进行系统评价和荟萃分析。独立审查员将通过电子数据库（Scopus、PubMed、EMBASE 和 Cochrane Library）和其他来源搜索已发表/未发表的研究，提取数据，并通过纽卡斯尔-渥太华量表评估方法学质量。将通过计算 Cohen's d 指数作为效应大小进行随机效应荟萃分析。将评估发表偏倚，并通过加权最小二乘法荟萃回归调查效应大小的调节因素。健康相关生活质量是否因某些个体特征而更好或更差的知识可能会根据精准医学方法建议个性化的护理途径。
伦理和传播
目前的审查不需要伦理批准。结果将通过在同行评议期刊上发表来传播。
PROSPERO 注册号：CRD42019131749。
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