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云康10绿茶膳食补充剂和跑步机运动改善高脂饮食诱导的C57BL/6 J小鼠代谢综合征。

Dietary supplement of Yunkang 10 green tea and treadmill exercise ameliorate high fat diet induced metabolic syndrome of C57BL/6 J mice.

作者信息

Zhang Yanzhong, Gu Mingxing, Wang Ruru, Li Menwan, Li Daxiang, Xie Zhongwen

机构信息

1Department of Sports Sciences, Anhui Agricultural University, Hefei, Anhui People's Republic of China.

2State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Sciences and Technology, Anhui Agricultural University, 130 West Changjiang Road, Hefei, Anhui Province 230036 People's Republic of China.

出版信息

Nutr Metab (Lond). 2020 Feb 4;17:14. doi: 10.1186/s12986-020-0433-9. eCollection 2020.

DOI:10.1186/s12986-020-0433-9
PMID:32042300
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7001212/
Abstract

BACKGROUND: Diet and exercise play important roles in ameliorating metabolic syndrome. Yunkang 10 () is a most cultivated tea variety for making tea in the Southwestern China. Currently, there is no report of healthy effects of Yunkang 10 green tea (YKGT) and treadmill exercise (Ex) on high fat diet induced metabolic syndrome (MetS). We aimed to investigate the beneficial effects and molecular mechanism of YKGT and Ex using high fat diet induced MetS of C57BL/6 mice. METHODS: Catechins and caffeine in water extract of YKGT were measured via high performance liquid chromatography (HPLC). 10-week old mice were fed with high fat diet (HFD) for 10 weeks to induce obese mice. Then the obese mice were fed with continuous high fat diet (HFD), HFD with YKGT, HFD with Ex, and HFD with both YKGT and Ex for 8 weeks, respectively. The another group of 10-week old mice fed with low fat diet (LFD) were used as control. RESULTS: HPLC data revealed that YKGT has abundantly high concentration of epigallocatechin gallate (EGCG) and caffeine compared to Longjing 43 () green tea. YKGT and Ex significantly decreased the level of blood glucose, serum total cholesterol (TC), triglyceride (TG), insulin, and alanine aminotransferase activity (ALT) when compared to HFD group. The fatty liver and hepatic pro-inflammatory gene expression in the YKGT, Ex and YKGT+Ex groups was mitigated significantly compared with HFD group, respectively. The phosphorylation of inhibitor of nuclear factor kappa-B kinase α/β (IKKα/β) and inhibitor of nuclear factor kappa-B α (IkBα) protein in the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) signaling pathway was also decreased in YKGT or YKGT+Ex groups. The combination of YKGT and Ex prevented gene expression for lipid synthesis in the liver tissue, and significantly upregulated mRNA level of glucose transport genes in the skeletal muscles, when compared to the HFD group. CONCLUSIONS: This study demonstrated that YKGT supplement or exercise appeared to reverse preexisting metabolic syndrome, and effectively relieved the fatty liver and hepatic inflammatory response induced by high fat diet. YKGT supplement and treadmill exercise together had better beneficial effects than only one intervention.

摘要

背景：饮食和运动在改善代谢综合征方面发挥着重要作用。云抗10号是中国西南部种植最多的制茶茶树品种。目前，尚无关于云抗10号绿茶（YKGT）和跑步机运动（Ex）对高脂饮食诱导的代谢综合征（MetS）健康影响的报道。我们旨在研究YKGT和Ex对高脂饮食诱导的C57BL/6小鼠代谢综合征的有益作用及其分子机制。 方法：通过高效液相色谱法（HPLC）测定YKGT水提取物中的儿茶素和咖啡因。将10周龄小鼠喂以高脂饮食（HFD）10周以诱导肥胖小鼠。然后，将肥胖小鼠分别连续喂以高脂饮食（HFD）、高脂饮食加YKGT、高脂饮食加Ex以及高脂饮食加YKGT和Ex，持续8周。另一组喂以低脂饮食（LFD）的10周龄小鼠用作对照。 结果：HPLC数据显示，与龙井43号绿茶相比，YKGT中表没食子儿茶素没食子酸酯（EGCG）和咖啡因的浓度极高。与HFD组相比，YKGT和Ex显著降低了血糖、血清总胆固醇（TC）、甘油三酯（TG）、胰岛素水平以及丙氨酸氨基转移酶活性（ALT）。与HFD组相比，YKGT组、Ex组和YKGT + Ex组的脂肪肝和肝脏促炎基因表达均显著减轻。YKGT组或YKGT + Ex组中，活化B细胞核因子κB轻链增强子（NF - kB）信号通路中核因子κB激酶α/β（IKKα/β）和核因子κBα抑制蛋白（IkBα）的磷酸化也降低。与HFD组相比，YKGT和Ex联合使用可抑制肝脏组织中脂质合成相关基因的表达，并显著上调骨骼肌中葡萄糖转运基因的mRNA水平。 结论：本研究表明，补充YKGT或进行运动似乎可以逆转已有的代谢综合征，并有效缓解高脂饮食诱导的脂肪肝和肝脏炎症反应。YKGT补充剂和跑步机运动联合使用比仅进行一种干预具有更好的有益效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/554c/7001212/524d7e3a220e/12986_2020_433_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/554c/7001212/52040448d116/12986_2020_433_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/554c/7001212/aafddddfa5f5/12986_2020_433_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/554c/7001212/1314a1546629/12986_2020_433_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/554c/7001212/e1b3948daa30/12986_2020_433_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/554c/7001212/524d7e3a220e/12986_2020_433_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/554c/7001212/52040448d116/12986_2020_433_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/554c/7001212/77904b927e76/12986_2020_433_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/554c/7001212/e44fe38996cb/12986_2020_433_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/554c/7001212/287ca8521251/12986_2020_433_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/554c/7001212/77f8f59bbeae/12986_2020_433_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/554c/7001212/de8a403c9c19/12986_2020_433_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/554c/7001212/aafddddfa5f5/12986_2020_433_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/554c/7001212/1314a1546629/12986_2020_433_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/554c/7001212/e1b3948daa30/12986_2020_433_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/554c/7001212/524d7e3a220e/12986_2020_433_Fig10_HTML.jpg

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本文引用的文献

[1]
Theabrownin from Pu-erh tea together with swinging exercise synergistically ameliorates obesity and insulin resistance in rats.

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