de la Fuente Muñoz Mario, de la Fuente Fernández María, Román-Carmena Marta, Iglesias de la Cruz Maria Del Carmen, Amor Sara, Martorell Patricia, Enrique-López María, García-Villalón Angel Luis, Inarejos-García Antonio Manuel, Granado Miriam
Physiology Department, Faculty of Medicine, Universidad Autónoma de Madrid, 28029 Madrid, Spain.
R&D Department Biopolis, 46980 Paterna, Spain.
Antioxidants (Basel). 2022 Aug 15;11(8):1573. doi: 10.3390/antiox11081573.
Hypertension is considered to be both a cardiovascular disease and a risk factor for other cardiovascular diseases, such as coronary ischemia or stroke. In many cases, hypertension occurs in the context of metabolic syndrome (MetS), a condition in which other circumstances such as abdominal obesity, dyslipidemia, and insulin resistance are also present. The high incidence of MetS makes necessary the search for new strategies, ideally of natural origin and with fewer side effects than conventional pharmacological treatments. Among them, the tea plant is a good candidate, as it contains several bioactive compounds such as caffeine, volatile terpenes, organic acids, and polyphenols with positive biological effects. The aim of this study was to assess whether two new standardized tea extracts, one of white tea (WTE) and the other of black and green tea (CTE), exert beneficial effects on the cardiovascular alterations associated with MetS. For this purpose, male C57/BL6J mice were fed a standard diet (Controls), a diet high in fats and sugars (HFHS), HFHS supplemented with 1.6% WTE, or HFHS supplemented with 1.6% CTE for 20 weeks. The chromatography results showed that CTE is more concentrated on gallic acid, xanthines and flavan-3-ols than WTE. In vivo, supplementation with WTE and CTE prevented the development of MetS-associated hypertension through improved endothelial function. This improvement was associated with a lower expression of proinflammatory and prooxidant markers, and-in the case of CTE supplementation-also with a higher expression of antioxidant enzymes in arterial tissue. In conclusion, supplementation with WTE and CTE prevents the development of hypertension in obese mice; as such, they could be an interesting strategy to prevent the cardiovascular disorders associated with MetS.
高血压被认为既是一种心血管疾病，也是其他心血管疾病（如冠状动脉缺血或中风）的危险因素。在许多情况下，高血压发生在代谢综合征（MetS）的背景下，代谢综合征是一种还存在腹部肥胖、血脂异常和胰岛素抵抗等其他情况的病症。代谢综合征的高发病率使得有必要寻找新的策略，理想情况下是天然来源且副作用比传统药物治疗更少的策略。其中，茶树是一个很好的候选者，因为它含有几种具有积极生物学效应的生物活性化合物，如咖啡因、挥发性萜类、有机酸和多酚。本研究的目的是评估两种新的标准化茶提取物，一种是白茶提取物（WTE），另一种是红茶和绿茶提取物（CTE），是否对与代谢综合征相关的心血管改变产生有益影响。为此，给雄性C57/BL6J小鼠喂食标准饮食（对照组）、高脂肪高糖饮食（HFHS）、添加1.6% WTE的HFHS或添加1.6% CTE的HFHS，持续20周。色谱分析结果表明，CTE中没食子酸、黄嘌呤和黄烷 - 3 - 醇的含量比WTE更高。在体内，补充WTE和CTE可通过改善内皮功能预防与代谢综合征相关的高血压的发展。这种改善与促炎和促氧化标志物的表达降低有关，并且——在补充CTE的情况下——还与动脉组织中抗氧化酶的表达升高有关。总之，补充WTE和CTE可预防肥胖小鼠高血压的发展；因此，它们可能是预防与代谢综合征相关的心血管疾病的一种有趣策略。
