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AV3 单链 DNA 适体通过 Ras-PI3K/MAPK 通路抑制血管平滑肌细胞增殖和迁移。

Av3 Single-Stranded DNA Aptamer Attenuates Vascular Smooth Muscle Cell Proliferation and Migration via Ras-PI3K/MAPK Pathway.

机构信息

Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan, China.

出版信息

Cardiovasc Ther. 2020 Jan 21;2020:6869856. doi: 10.1155/2020/6869856. eCollection 2020.

DOI:10.1155/2020/6869856
PMID:32042311
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6995496/
Abstract

OBJECTIVES: To observe the effect of av3 single-stranded (ss) DNA on proliferation and migration of vascular smooth muscle cells (VSMCs) and its potential mechanism. BACKGROUND: Percutaneous transluminal coronary angioplasty (PTCA) is currently the preferred method for the treatment of coronary heart disease. However, vascular restenosis still occurs after PTCA treatment, severely affecting the clinical efficacy of PTCA. Integrin av3 single-stranded (ss) DNA on proliferation and migration of vascular smooth muscle cells (VSMCs) and its potential mechanism. METHODS: In this experiment, we used systematic evolution of ligands by exponential enrichment (SELEX) to screen out av3 single-stranded (ss) DNA on proliferation and migration of vascular smooth muscle cells (VSMCs) and its potential mechanism. 3 single-stranded (ss) DNA on proliferation and migration of vascular smooth muscle cells (VSMCs) and its potential mechanism. 3 single-stranded (ss) DNA on proliferation and migration of vascular smooth muscle cells (VSMCs) and its potential mechanism. 3 single-stranded (ss) DNA on proliferation and migration of vascular smooth muscle cells (VSMCs) and its potential mechanism. RESULTS: In the present study, we found that av3 single-stranded (ss) DNA on proliferation and migration of vascular smooth muscle cells (VSMCs) and its potential mechanism. < 0.05). Av3 single-stranded (ss) DNA on proliferation and migration of vascular smooth muscle cells (VSMCs) and its potential mechanism. < 0.05). Av < 0.05). Av. CONCLUSIONS: The findings suggest that av3 ssDNA inhibited the proliferation and migration of VSMCs by suppressing the activation of Ras-PI3K/MAPK signaling.3 single-stranded (ss) DNA on proliferation and migration of vascular smooth muscle cells (VSMCs) and its potential mechanism.

摘要

目的：观察 av3 单链（ss）DNA 对血管平滑肌细胞（VSMCs）增殖和迁移的影响及其潜在机制。

背景：经皮腔内冠状动脉成形术（PTCA）目前是治疗冠心病的首选方法。然而，PTCA 治疗后仍会发生血管再狭窄，严重影响 PTCA 的临床疗效。整合素 av3 单链（ss）DNA 对血管平滑肌细胞（VSMCs）增殖和迁移的影响及其潜在机制。

方法：在本实验中，我们使用指数富集的配体系统进化（SELEX）筛选出 av3 单链（ss）DNA 对血管平滑肌细胞（VSMCs）增殖和迁移的影响及其潜在机制。

结果：本研究发现，av3 单链（ss）DNA 可通过抑制 Ras-PI3K/MAPK 信号通路的激活抑制 VSMCs 的增殖和迁移（P<0.05）。

结论：这些发现表明，av3 ssDNA 通过抑制 Ras-PI3K/MAPK 信号通路的激活来抑制 VSMCs 的增殖和迁移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/6995496/598225673435/CDTP2020-6869856.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/6995496/faf784bd0230/CDTP2020-6869856.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/6995496/6d9bd5b3d8a4/CDTP2020-6869856.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/6995496/47013fe9dce9/CDTP2020-6869856.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/6995496/9dac30cfa2c1/CDTP2020-6869856.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/6995496/22f9211c7374/CDTP2020-6869856.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/6995496/598225673435/CDTP2020-6869856.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/6995496/faf784bd0230/CDTP2020-6869856.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/6995496/6d9bd5b3d8a4/CDTP2020-6869856.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/6995496/47013fe9dce9/CDTP2020-6869856.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/6995496/9dac30cfa2c1/CDTP2020-6869856.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/6995496/22f9211c7374/CDTP2020-6869856.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/6995496/598225673435/CDTP2020-6869856.006.jpg

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本文引用的文献

[1]
DNA aptamers from whole-serum SELEX as new diagnostic agents against gastric cancer.

RSC Adv. 2019-1-9

[2]
Osteopontin mediates murine transfusion-related acute lung injury via stimulation of pulmonary neutrophil accumulation.

Blood. 2019-5-10

[3]
Graphene-Induced Osteogenic Differentiation Is Mediated by the Integrin/FAK Axis.

Int J Mol Sci. 2019-1-29

[4]
Novel benzotriazole N-acylarylhydrazone hybrids: Design, synthesis, anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis and FAK inhibition.

Bioorg Chem. 2018-7-10

[5]
Nesfatin-1 functions as a switch for phenotype transformation and proliferation of VSMCs in hypertensive vascular remodeling.

Biochim Biophys Acta Mol Basis Dis. 2018-4-5

[6]
Promoted Delivery of Salinomycin to Lung Cancer Through Epidermal Growth Factor Receptor Aptamers Coupled DSPE-PEG2000 Nanomicelles.

J Nanosci Nanotechnol. 2018-8-1

[7]
Aptamer-mediated impairment of EGFR-integrin αvβ3 complex inhibits vasculogenic mimicry and growth of triple-negative breast cancers.

Sci Rep. 2017-4-20

[8]
SM22α inhibits lamellipodium formation and migration via Ras-Arp2/3 signaling in synthetic VSMCs.

Am J Physiol Cell Physiol. 2016-11-1

[9]
Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells.

Mol Ther Nucleic Acids. 2016-1-5

[10]
Enhanced Expression of Integrin αvβ3 Induced by TGF-β Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-β-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells.

PLoS One. 2015-9-3

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