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lncRNA-SNHG14 通过海绵 miR-19a-3p 调控 ROR 表达促进动脉粥样硬化。

lncRNA-SNHG14 Promotes Atherosclerosis by Regulating ROR Expression through Sponge miR-19a-3p.

机构信息

Department of Physiology, Jining Medical College, Jining, Shandong, China.

Department of Pharmacy, Jining Medical College, Jining, Shandong, China.

出版信息

Comput Math Methods Med. 2020 Aug 25;2020:3128053. doi: 10.1155/2020/3128053. eCollection 2020.

DOI:10.1155/2020/3128053
PMID:32908577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7468621/
Abstract

Coronary heart disease (CHD) is the most common cardiovascular disease with high prevalence, disability, and mortality. The balance between proliferation and apoptosis of vascular smooth muscle cells (VSMCs) plays a key role in the initiation of atherosclerosis. In this study, we found a significant decrease in the expression of lncRNA-SNHG14 in atherosclerotic plaque tissues of ApoE-/- mice. Overexpression of lncRNA-SNHG14 can inhibit VSMC proliferation while promoting apoptosis. There is a potential reciprocal regulatory relationship between lncRNASNHG14 and miR-19a-3p, which inhibit each other's expression in vascular smooth muscle cells. In addition, the luciferase reporter gene analysis results showed that there was a direct interaction between miR-19a-3p and the 3'UTR of ROR. The results of qRT-PCR showed that the level of ROR mRNA was significantly increased in the aortas treated with miR-19a-3p and SNHG14 compared with that treated with miR-19a-3p alone. In conclusion, we demonstrated that lncRNA-SNHG14 regulates the apoptosis/proliferation balance of VSMCs in atherosclerosis.

摘要

冠心病（CHD）是最常见的心血管疾病，具有高患病率、高致残率和高死亡率。血管平滑肌细胞（VSMCs）的增殖和凋亡平衡在动脉粥样硬化的发生中起着关键作用。在本研究中，我们发现载脂蛋白 E 基因敲除（ApoE-/-）小鼠动脉粥样硬化斑块组织中 lncRNA-SNHG14 的表达显著降低。lncRNA-SNHG14 的过表达可以抑制 VSMC 的增殖，同时促进其凋亡。lncRNA-SNHG14 和 miR-19a-3p 之间存在潜在的相互调节关系，它们在血管平滑肌细胞中相互抑制表达。此外，荧光素酶报告基因分析结果表明 miR-19a-3p 与 ROR 的 3'UTR 之间存在直接相互作用。qRT-PCR 结果显示，与单独转染 miR-19a-3p 相比，转染 miR-19a-3p 和 SNHG14 可使主动脉中 ROR mRNA 的水平显著升高。综上所述，我们证明了 lncRNA-SNHG14 调节动脉粥样硬化中 VSMCs 的凋亡/增殖平衡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7231/7468621/cbed5eb22278/CMMM2020-3128053.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7231/7468621/f5bf8c17d781/CMMM2020-3128053.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7231/7468621/2776bbeaf651/CMMM2020-3128053.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7231/7468621/8f184f4acf87/CMMM2020-3128053.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7231/7468621/535088465aab/CMMM2020-3128053.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7231/7468621/cbed5eb22278/CMMM2020-3128053.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7231/7468621/f5bf8c17d781/CMMM2020-3128053.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7231/7468621/2776bbeaf651/CMMM2020-3128053.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7231/7468621/8f184f4acf87/CMMM2020-3128053.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7231/7468621/535088465aab/CMMM2020-3128053.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7231/7468621/cbed5eb22278/CMMM2020-3128053.005.jpg

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引用本文的文献

[1]
Role of LncRNAs in the Pathogenesis of Coronary Artery Disease.

Rev Cardiovasc Med. 2023-3-23

[2]
Retracted: lncRNA-SNHG14 Promotes Atherosclerosis by Regulating ROR Expression through Sponge miR-19a-3p.

Comput Math Methods Med. 2023-9-20

[3]
LncRNAs as Regulators of Atherosclerotic Plaque Stability.

Cells. 2023-7-12

[4]
The diverse roles of macrophages in metabolic inflammation and its resolution.

Front Cell Dev Biol. 2023-3-13

[5]
Long noncoding RNA DANCR expression and its predictive value in patients with atherosclerosis.

Bioengineered. 2022-3

[6]
lncRNA promotes atherosclerosis progression by targeting miR-382-5p.

Int J Clin Exp Pathol. 2021-9-15

[7]
Dysregulation Serum miR-19a-3p is a Diagnostic Biomarker for Asymptomatic Carotid Artery Stenosis and a Promising Predictor of Cerebral Ischemia Events.

Clin Appl Thromb Hemost. 2021

[8]
Long noncoding RNA SNHG10 promotes colorectal cancer cells malignant progression by targeting miR-3690.

Bioengineered. 2021-12

[9]
LncRNA APOA1-AS facilitates proliferation and migration and represses apoptosis of VSMCs through TAF15-mediated SMAD3 mRNA stabilization.

Cell Cycle. 2021-9

[10]
Mechanism of Autonomic Exercise Improving Cognitive Function of Alzheimer's Disease by Regulating lncRNA SNHG14.

Am J Alzheimers Dis Other Demen. 2021

本文引用的文献

[1]
Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR-204-5p/DPP4 signaling in valvular interstitial cells.

J Pineal Res. 2020-9

[2]
Vessel graft fabricated by the on-site differentiation of human mesenchymal stem cells towards vascular cells on vascular extracellular matrix scaffold under mechanical stimulation in a rotary bioreactor.

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Arterioscler Thromb Vasc Biol. 2019-7-25

[10]
Prognostic Implications of Plaque Characteristics and Stenosis Severity in Patients With Coronary Artery Disease.

J Am Coll Cardiol. 2019-5-21

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