Department of Health Science, California State University, Long Beach, CA, USA.
Department of Psychology, San Diego State University, San Diego, CA, USA.
Ann Behav Med. 2020 Jun 12;54(7):529-534. doi: 10.1093/abm/kaz070.
Inflammation is implicated as one of many factors related to the development of chronic disease; thus, identifying its modifiable risk factors offers potential intervention targets to reduce risk.
To investigate whether depression and anxiety symptoms may indirectly affect high-sensitivity C-reactive protein (hs-CRP) and plasminogen activator inhibitor-1 (PAI-1) through sleep duration and adiposity (i.e., percentage body fat and waist circumference).
Multiple regression analyses were performed on Hispanic Community Health Study/Study of Latinos Youth (ages 8-16 years) cross-sectional baseline data, which were weighted to adjust for sampling design. Data were collected at a clinical assessment, including fasting blood samples, self-report surveys, and objectively measured anthropometrics.
Adjusting for sociodemographic covariates, depression symptoms were associated with log hs-CRP (β = .011, p = .047) but not PAI-1 (p = .285). Percentage body fat and waist circumference were positively related to depression symptoms (p = .026 and p = .028, respectively) and log hs-CRP (p < .001 for both). When including adiposity in the hs-CRP model, the associations of depression symptoms with hs-CRP were attenuated and became nonsignificant. Monte Carlo confidence intervals (CIs) showed that the indirect effects from depression symptoms to CRP through percentage body fat (95% CI: .0006, .0119) and waist circumference (95% CI: .0004, .0109) were statistically significant.
Results indicate that the association between psychological distress and inflammation may occur indirectly through adiposity in Hispanic/Latino children. If findings are replicated in causal designs, reducing depression symptoms and adiposity among Hispanic/Latino children may be avenues for primary prevention of inflammation in later years.
炎症是与慢性病发展相关的众多因素之一；因此，确定其可改变的危险因素为降低风险提供了潜在的干预靶点。
研究抑郁和焦虑症状是否通过睡眠时间和肥胖（即体脂肪百分比和腰围）间接影响高敏 C 反应蛋白（hs-CRP）和纤溶酶原激活物抑制剂-1（PAI-1）。
对西班牙裔社区健康研究/拉丁裔青少年研究（年龄 8-16 岁）的横断面基线数据进行了多元回归分析，这些数据经过加权处理，以调整抽样设计。数据是在临床评估中收集的，包括空腹血样、自我报告调查和客观测量的人体测量学数据。
调整社会人口学协变量后，抑郁症状与 log hs-CRP（β=0.011，p=0.047）相关，但与 PAI-1 无关（p=0.285）。体脂肪百分比和腰围与抑郁症状呈正相关（p=0.026 和 p=0.028），与 log hs-CRP 也呈正相关（两者均 p<0.001）。在 hs-CRP 模型中纳入肥胖因素后，抑郁症状与 hs-CRP 的相关性减弱且变得无统计学意义。蒙特卡罗置信区间（CI）显示，抑郁症状通过体脂肪（95%CI：0.0006，0.0119）和腰围（95%CI：0.0004，0.0109）对 CRP 的间接影响具有统计学意义。
结果表明，在西班牙裔/拉丁裔儿童中，心理困扰与炎症之间的关联可能通过肥胖间接发生。如果在因果设计中得到复制，那么减少西班牙裔/拉丁裔儿童的抑郁症状和肥胖可能是预防日后炎症的主要途径。
