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撤回:微小RNA let-7b通过NRAS阻断Ras/Rho信号通路抑制去势抵抗性前列腺癌细胞的增殖并诱导其凋亡。

Retracted: MicroRNA let-7b Inhibits Proliferation and Induces Apoptosis of Castration-Resistant Prostate Cancer Cells by Blocking the Ras/Rho Signaling Pathway via NRAS.

出版信息

Clin Transl Sci. 2021 Sep;14(5):2055-2064. doi: 10.1111/cts.12743. Epub 2020 Apr 22.

DOI:10.1111/cts.12743
PMID:32043299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8504823/
Abstract

Retraction: Huang, L., Wang, L., Wang, L., Wu, Z., Jiang, F., Li, Q., & Wang, S. MicroRNA let-7b Inhibits Proliferation and Induces Apoptosis of Castration-Resistant Prostate Cancer Cells by Blocking the Ras/Rho Signaling Pathway via NRAS, Clin. Trans. Sci. https://ascpt.onlinelibrary.wiley.com/doi/full/10.1111/cts.12743 The above article, published online on February 10, 2020 in Wiley Online Library, has been retracted by mutual agreement among the authors, the journal Editor-in-Chief, Dr. John Wagner, the American Society for Clinical Pharmacology and Therapeutics, and John Wiley & Sons, Inc. The retraction has been issued at the authors' request. After questions were raised about the validity of the Western blots, the authors expanded the sample size and repeated the experiment. The results could not be confirmed and do not fully support the conclusions made in the article.

摘要

撤稿声明

黄,L.,王,L.,王,L.,吴,Z.,姜,F.,李,Q.,& 王,S.《微小RNA let-7b通过NRAS阻断Ras/Rho信号通路抑制去势抵抗性前列腺癌细胞的增殖并诱导其凋亡》,《临床转化科学》,https://ascpt.onlinelibrary.wiley.com/doi/full/10.1111/cts.12743 上述文章于2020年2月10日在线发表于威利在线图书馆,已由作者、期刊主编约翰·瓦格纳博士、美国临床药理学与治疗学会以及约翰·威利父子公司共同协商撤稿。撤稿是应作者要求发布的。在对蛋白质免疫印迹法的有效性提出质疑后,作者扩大了样本量并重复了实验。结果无法得到证实,且不完全支持文章中的结论。

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