Lukowiak K, Colebrook E
Neuroscience Research Group, Faculty of Medicine, University of Calgary, Alberta, Canada.
J Exp Biol. 1988 Nov;140:273-85. doi: 10.1242/jeb.140.1.273.
In a semi-intact preparation of Aplysia californica Cooper, classical conditioning training leads to changes in the synaptic strength at the sensory-motor neurone synapse. However, these changes are neither necessary nor sufficient to bring about the observed behavioural changes of the gill withdrawal reflex. We therefore tested whether the ability of a gill motor neurone to elicit a gill withdrawal response was altered following classical conditioning training of the reflex. We found that following classical conditioning training, the ability of a gill motor neurone to elicit a gill withdrawal response was significantly potentiated. In addition, in control preparations which did not receive classical conditioning training, the ability of a gill motor neurone to elicit a gill response was decreased. Thus, associative learning of this reflex appears to involve alteration in neuronal activity at loci distal to the sensory-motor neurone synapse.
在加利福尼亚海兔（Aplysia californica Cooper）的半完整标本中，经典条件反射训练会导致感觉运动神经元突触处的突触强度发生变化。然而，这些变化对于引发观察到的鳃收缩反射行为变化而言，既非必要条件也非充分条件。因此，我们测试了在对该反射进行经典条件反射训练后，鳃运动神经元引发鳃收缩反应的能力是否发生了改变。我们发现，经过经典条件反射训练后，鳃运动神经元引发鳃收缩反应的能力显著增强。此外，在未接受经典条件反射训练的对照标本中，鳃运动神经元引发鳃反应的能力有所下降。因此，这种反射的联想学习似乎涉及感觉运动神经元突触远端位点的神经元活动改变。
