Lukowiak K
J Neurobiol. 1986 Mar;17(2):83-101. doi: 10.1002/neu.480170204.
An in vitro preparation consisting of the siphon, mantle, gill, and abdominal ganglion undergoes classical conditioning when a weak tactile stimulus (CS) applied to the siphon is paired with a strong tactile stimulus to the gill (UCS). When the stimuli are paired, the CS comes to evoke a gill withdrawal reflex (GWR) which increases in amplitude with training. Only when the stimuli are paired in a classical conditioning paradigm does the CS come to evoke a GWR. With classical conditioning training there is an alteration in the synaptic efficacy between central sensory neurons and central gill motor neurons. Moreover, these changes can be observed in sensory neurons not activated by the CS. The changes observed, as evidence by the number of action potentials evoked in the gill motor neuron do not completely parallel the observed behavioral changes. It is suggested that in addition to changes in the synaptic efficacy at the sensory-motor neuron synapse, other changes in neuronal activity occur at other loci which lead to the observed behavioral changes.
一种由虹吸管、外套膜、鳃和腹神经节组成的体外制剂，当施加于虹吸管的弱触觉刺激（条件刺激）与施加于鳃的强触觉刺激（非条件刺激）配对时，会经历经典条件反射。当刺激配对时，条件刺激会引发鳃收缩反射（GWR），且该反射幅度会随着训练而增加。只有当刺激在经典条件反射范式中配对时，条件刺激才会引发鳃收缩反射。通过经典条件反射训练，中枢感觉神经元和中枢鳃运动神经元之间的突触效能会发生改变。此外，在未被条件刺激激活的感觉神经元中也能观察到这些变化。所观察到的变化，如通过鳃运动神经元诱发的动作电位数量所证明的，并不完全与所观察到的行为变化平行。有人认为，除了感觉运动神经元突触处的突触效能变化外，神经元活动在其他位点也会发生其他变化，从而导致所观察到的行为变化。
