Department of Rheumatology, University of Health Sciences, Bursa Yüksek Ihtisas Training and Research Hospital, Bursa, Turkey.
Department of Rheumatology, Necmettin Erbakan University, Konya, Turkey.
Scand J Rheumatol. 2020 May;49(3):233-238. doi: 10.1080/03009742.2019.1675183. Epub 2020 Feb 11.
: There has been no previous study comparing the frequency of sicca symptoms and Sjögren's syndrome (SS) in coeliac patients (CPs) and healthy controls (HCs) using a tight screening method. The aim of this study was to compare the frequency of sicca symptoms and SS in HCs and CPs.: The study included 80 CPs and 100 HCs. This study was designed as a case-control study with four phases. The frequency of SS in CPs and HCs was defined according to the 2002 American-European Consensus Group (AECG) and 2012 American College of Rheumatology (ACR) classification criteria. The frequency of sicca symptoms and SS was compared between CPs and HCs.: Ocular and oral symptoms occurred in 22% and 26% of CPs, respectively, compared to 13% and 10% of HCs, respectively. Proportions with oral symptoms were statistically significantly different between CPs and HCs (p = 0.005), whereas there was no significant difference for ocular symptoms (p = 0.113). According to ACR and AECG criteria, the prevalence of SS was 3.8% and 5.0% in CPs and 3.0% and 2.0% in HCs, respectively.: Although oral symptoms were more frequent in CPs than in HCs, the frequency of SS was not different between the groups. The increased frequency of oral symptoms may be related to reasons other than autoimmunity.
: 以前没有研究使用严格的筛选方法比较乳糜泻患者(CPs)和健康对照(HCs)中干燥症状和干燥综合征(SS)的频率。本研究旨在比较 HCs 和 CPs 中干燥症状和 SS 的频率。: 该研究纳入了 80 名 CPs 和 100 名 HCs。该研究设计为具有四个阶段的病例对照研究。CPs 和 HCs 中 SS 的频率根据 2002 年美国-欧洲共识组(AECG)和 2012 年美国风湿病学会(ACR)分类标准定义。比较了 CPs 和 HCs 之间干燥症状和 SS 的频率。: 眼部和口腔症状分别在 22%和 26%的 CPs 中发生,而在 13%和 10%的 HCs 中发生。CPs 和 HCs 之间口腔症状的比例有统计学显著差异(p = 0.005),而眼部症状无显著差异(p = 0.113)。根据 ACR 和 AECG 标准,SS 在 CPs 中的患病率分别为 3.8%和 5.0%,在 HCs 中的患病率分别为 3.0%和 2.0%。: 尽管 CPs 中的口腔症状比 HCs 更常见,但 SS 的频率在两组之间没有差异。口腔症状的频率增加可能与自身免疫以外的原因有关。