Pediatric Gastroenterology and Endoscopy Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genova, 16132 Genoa, Italy.
Nutrients. 2023 Dec 26;16(1):83. doi: 10.3390/nu16010083.
Celiac disease (CD) is an immune-mediated systemic gluten-related disorder characterized by a wide spectrum of intestinal and extra-intestinal manifestations, including damage to cutaneous and connective tissue. We report a rare case of chronic severe dermatitis involving connective tissue and cutaneous vascular vessels as the main clinical presentation of undiagnosed seronegative gluten disorder. A gluten-free diet dramatically improved the intestinal and cutaneous clinical damage in the patient. Pitfalls and the steps of differential diagnosis are described. We also review the literature regarding studies of CD and connective tissue diseases to extend the knowledge of these rare associations. We propose a practical diagnostic approach in suspected CD in autoimmune cutaneous disorders.
乳糜泻（CD）是一种免疫介导的全身性麸质相关疾病，其特征是广泛的肠道和肠道外表现，包括皮肤和结缔组织损伤。我们报告了一例罕见的慢性严重皮炎，其主要临床表现为未确诊的血清阴性麸质紊乱，涉及结缔组织和皮肤血管。无麸质饮食显著改善了患者的肠道和皮肤临床损伤。描述了陷阱和鉴别诊断步骤。我们还回顾了关于 CD 和结缔组织疾病的研究文献，以扩展对这些罕见关联的认识。我们建议在自身免疫性皮肤疾病中疑似 CD 时采用实用的诊断方法。
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