Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
Department of Ophthalmology, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2020 Nov 23;35(45):e369. doi: 10.3346/jkms.2020.35.e369.
To estimate the prevalence of Sjögren's syndrome (SS) in patients with rheumatoid arthritis (RA) and to compare the clinical features of RA patients with and without SS.
We conducted a retrospective study of RA patients who visited a rheumatology clinic in a tertiary referral hospital in Korea between May 20 and July 22, 2016. All patients fulfilled the classification criteria for RA, and the diagnosis of SS was made clinically by rheumatologists and according to the 2002 American-European Consensus Group (AECG), 2012 American College of Rheumatology (ACR), and 2016 ACR/European League Against Rheumatism (EULAR) classification criteria. The prevalence was estimated as the number of SS patients within the total number of RA patients. The disease activity and treatment pattern of RA were compared between patients with and without SS.
Among 827 RA patients, 72 patients (8.7%) were diagnosed with SS by a rheumatologist, though only 60 patients (7.3%) satisfied the 2002 AECG classification criteria for SS. Fifty-two patients (6.3%) and 56 patients (6.8%) fulfilled the 2012 ACR and 2016 ACR/EULAR classification criteria, respectively. The prevalence of SS in RA patients was 10.5%, 17.0%, and 67.6% in rheumatoid factor, antinuclear antibody (≥ 1:80), and anti-Ro antibody positive patients, respectively.
The prevalence of SS among RA patients was 8.7% according to rheumatologists' diagnosis. The presence of SS did not affect the treatment patterns of RA patients. However, the autoantibody profiles and demographics of RA patients with SS differed from those of patients without SS.
评估类风湿关节炎（RA）患者中干燥综合征（SS）的患病率，并比较有和无 SS 的 RA 患者的临床特征。
我们对 2016 年 5 月 20 日至 7 月 22 日在韩国一家三级转诊医院的风湿病诊所就诊的 RA 患者进行了回顾性研究。所有患者均符合 RA 的分类标准，SS 的诊断由风湿病医生根据 2002 年美国欧洲共识组（AECG）、2012 年美国风湿病学会（ACR）和 2016 年 ACR/欧洲抗风湿病联盟（EULAR）分类标准进行临床诊断。患病率估计为 SS 患者人数与 RA 患者总数的比值。比较了有和无 SS 的 RA 患者的疾病活动度和治疗模式。
在 827 例 RA 患者中，有 72 例（8.7%）被风湿病医生诊断为 SS，但只有 60 例（7.3%）符合 2002 年 AECG 的 SS 分类标准。52 例（6.3%）和 56 例（6.8%）分别符合 2012 年 ACR 和 2016 年 ACR/EULAR 分类标准。在类风湿因子、抗核抗体（≥ 1:80）和抗 Ro 抗体阳性的 RA 患者中，SS 的患病率分别为 10.5%、17.0%和 67.6%。
根据风湿病医生的诊断，RA 患者中 SS 的患病率为 8.7%。SS 的存在并不影响 RA 患者的治疗模式。然而，有 SS 的 RA 患者的自身抗体谱和人口统计学特征与无 SS 的患者不同。
