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1
Sicca Syndrome Induced by Immune Checkpoint Inhibitor Therapy: Optimal Management Still Pending.免疫检查点抑制剂治疗导致的干燥综合征：最佳治疗方案仍有待确定。
Oncologist. 2020 Feb;25(2):e391-e395. doi: 10.1634/theoncologist.2019-0467. Epub 2019 Nov 6.
2
[Characteristics of keratoconjunctivitis sicca in Sjögren's disease and syndrome].[干燥综合征中干燥性角结膜炎的特征]
Ter Arkh. 1988;60(4):30-1.
3
Ultrasonographic contrast-enhanced study of sicca syndrome.干燥综合征的超声造影研究
Eur J Radiol. 2005 May;54(2):225-32. doi: 10.1016/j.ejrad.2004.04.018.
4
The EULAR Sjogren's syndrome patient reported index as an independent determinant of health-related quality of life in primary Sjogren's syndrome patients: in comparison with non-Sjogren's sicca patients.EULAR 干燥综合征患者报告指数是原发性干燥综合征患者健康相关生活质量的独立决定因素：与非干燥综合征干燥患者相比。
Rheumatology (Oxford). 2013 Dec;52(12):2208-17. doi: 10.1093/rheumatology/ket270. Epub 2013 Sep 10.
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Sicca/Sjögren's syndrome triggered by PD-1/PD-L1 checkpoint inhibitors. Data from the International ImmunoCancer Registry (ICIR).由 PD-1/PD-L1 检查点抑制剂引发的干燥综合征/舍格伦综合征。来自国际免疫癌症登记处（ICIR）的数据。
Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):114-122. Epub 2019 Aug 28.
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Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca.干燥综合征角膜结膜炎患者泪液和结膜中细胞因子平衡的改变。
Curr Eye Res. 1999 Sep;19(3):201-11. doi: 10.1076/ceyr.19.3.201.5309.
7
Prevalence of Sjögren's syndrome in autoimmune diseases.自身免疫性疾病中干燥综合征的患病率。
Ann Rheum Dis. 1987 Apr;46(4):286-9. doi: 10.1136/ard.46.4.286.
8
Salivary gland and peripheral blood T helper 1 and 2 cell activity in Sjögren's syndrome compared with non-Sjögren's sicca syndrome.干燥综合征与非干燥综合征性口干症患者唾液腺及外周血辅助性T细胞1和辅助性T细胞2活性的比较
Ann Rheum Dis. 2005 Oct;64(10):1474-9. doi: 10.1136/ard.2004.031781. Epub 2005 Apr 7.
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Beneficial effect of topical fibronectin in patients with keratoconjunctivitis sicca of Sjögren's syndrome.局部应用纤连蛋白对干燥综合征性角结膜炎患者的有益作用。
J Rheumatol. 1985 Jun;12(3):487-9.
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Characterization of sicca symptoms in patients with Sjögren's syndrome, and reports of six cases lacking subjective sicca features ("subclinical Sjögren's syndrome").干燥综合征患者干燥症状的特征，以及6例无主观干燥特征患者（“亚临床干燥综合征”）的报告。
Tokai J Exp Clin Med. 1981 Jul;6(3):229-40.

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Oral Immune-Related Adverse Events Caused by Immune Checkpoint Inhibitors: Salivary Gland Dysfunction and Mucosal Diseases.免疫检查点抑制剂引起的口腔免疫相关不良事件：唾液腺功能障碍和黏膜疾病
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Dermatologic immune-related adverse events: The toxicity spectrum and recommendations for management.皮肤免疫相关不良事件：毒性谱及管理建议。
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Rheumatic Manifestations and Diseases From Immune Checkpoint Inhibitors in Cancer Immunotherapy.癌症免疫治疗中免疫检查点抑制剂引起的风湿性表现和疾病
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Rheumatic Immune-Related Adverse Events-A Consequence of Immune Checkpoint Inhibitor Therapy.风湿免疫相关不良事件——免疫检查点抑制剂治疗的后果
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本文引用的文献

1
Sicca Syndrome Associated with Immune Checkpoint Inhibitor Therapy.干燥综合征与免疫检查点抑制剂治疗相关。
Oncologist. 2019 Sep;24(9):1259-1269. doi: 10.1634/theoncologist.2018-0823. Epub 2019 Apr 17.
2
A severe case of neuro-Sjögren's syndrome induced by pembrolizumab.由派姆单抗引发的严重神经斯耶格伦综合征病例。
J Immunother Cancer. 2018 Oct 22;6(1):110. doi: 10.1186/s40425-018-0429-4.
3
Rheumatic immune-related adverse events in patients on anti-PD-1 inhibitors: Fasciitis with myositis syndrome as a new complication of immunotherapy.抗 PD-1 抑制剂治疗患者的风湿免疫相关不良事件：肌炎综合征伴筋膜炎作为免疫治疗的一种新并发症。
Autoimmun Rev. 2018 Oct;17(10):1040-1045. doi: 10.1016/j.autrev.2018.05.002. Epub 2018 Aug 10.
4
Nivolumab-induced sialadenitis.纳武单抗诱发的涎腺炎。
Respirol Case Rep. 2018 Apr 15;6(5):e00322. doi: 10.1002/rcr2.322. eCollection 2018 Jul.
5
Gougerot-Sjogren-like syndrome under PD-1 inhibitor treatment.程序性死亡蛋白1（PD-1）抑制剂治疗下的 Gougerot-Sjogren样综合征
Ann Oncol. 2017 Dec 1;28(12):3108. doi: 10.1093/annonc/mdx531.
6
Rheumatic immune-related adverse events of checkpoint therapy for cancer: case series of a new nosological entity.癌症检查点疗法的风湿免疫相关不良事件：一种新病种实体的病例系列
RMD Open. 2017 Mar 20;3(1):e000412. doi: 10.1136/rmdopen-2016-000412. eCollection 2017.
7
Onset of connective tissue disease following anti-PD1/PD-L1 cancer immunotherapy.抗PD1/PD-L1癌症免疫治疗后结缔组织病的发病情况。
Ann Rheum Dis. 2018 Mar;77(3):468-470. doi: 10.1136/annrheumdis-2016-210820. Epub 2017 Feb 27.
8
Oral mucosal changes induced by anticancer targeted therapies and immune checkpoint inhibitors.抗癌靶向治疗和免疫检查点抑制剂引起的口腔黏膜变化
Support Care Cancer. 2017 May;25(5):1713-1739. doi: 10.1007/s00520-017-3629-4. Epub 2017 Feb 22.
9
2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome: A consensus and data-driven methodology involving three international patient cohorts.2016 年美国风湿病学会/欧洲抗风湿病联盟原发性干燥综合征分类标准：一项涉及三个国际患者队列的共识和数据驱动方法。
Ann Rheum Dis. 2017 Jan;76(1):9-16. doi: 10.1136/annrheumdis-2016-210571. Epub 2016 Oct 26.
10
Inflammatory arthritis and sicca syndrome induced by nivolumab and ipilimumab.纳武单抗和伊匹单抗诱发的炎性关节炎和干燥综合征。
Ann Rheum Dis. 2017 Jan;76(1):43-50. doi: 10.1136/annrheumdis-2016-209595. Epub 2016 Jun 15.

免疫检查点抑制剂治疗导致的干燥综合征：最佳治疗方案仍有待确定。

Sicca Syndrome Induced by Immune Checkpoint Inhibitor Therapy: Optimal Management Still Pending.

机构信息

Hospital Santa Caterina, Girona, Spain.

Department of Oncodermatology, Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France.

出版信息

Oncologist. 2020 Feb;25(2):e391-e395. doi: 10.1634/theoncologist.2019-0467. Epub 2019 Nov 6.

DOI:10.1634/theoncologist.2019-0467
PMID:32043780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7011671/
Abstract

Commenting on a recently published article on sicca syndrome linked to immune checkpoint inhibitor therapy, this letter to the editor shares another viewpoint on the management of this immune‐related adverse event.

摘要

针对最近发表的一篇关于免疫检查点抑制剂治疗相关干燥综合征的文章，这封给编辑的信分享了另一种观点，即如何管理这种免疫相关不良事件。