Department of General Medicine, Taizhou First People's Hospital, Zhejiang, China.
Department of General Medicine, Taizhou First People's Hospital, Zhejiang, China.
Neurosci Lett. 2020 Mar 23;722:134824. doi: 10.1016/j.neulet.2020.134824. Epub 2020 Feb 7.
There is accumulating evidence that the association of apolipoprotein E4 (APOE4) with the risk of developing Alzheimer's disease (AD) is modified by sex. However, the associations of APOE4 status and sex with AD-related markers in older adults with significant memory concern (SMC) remain elusive. Among individuals with SMC (n = 106), we investigated the associations of APOE4 status and sex with multiple AD-related markers, including verbal memory, hippocampal volumes, cerebral glucose metabolism and cortical amyloid burden. In individuals with SMC, we found a significant APOE4*sex interaction for cerebral glucose metabolism, but not verbal memory, hippocampal volumes or cortical amyloid burden. Specifically, female APOE4 carriers showed significantly higher cerebral glucose metabolism compared to female APOE4 non-carriers whereas male APOE4 carriers had lower cerebral glucose metabolism than male APOE4-noncarriers. In conclusion, the effect of APOE4 on cerebral glucose metabolism is altered by sex in individuals with SMC.
越来越多的证据表明，载脂蛋白 E4（APOE4）与阿尔茨海默病（AD）发病风险的关联受到性别的影响。然而，APOE4 状态和性别与有明显记忆问题（SMC）的老年人 AD 相关标志物的关联仍不清楚。在 SMC 患者（n=106）中，我们研究了 APOE4 状态和性别与多种 AD 相关标志物的关联，包括语言记忆、海马体积、脑葡萄糖代谢和皮质淀粉样蛋白负担。在 SMC 患者中，我们发现脑葡萄糖代谢与 APOE4*性别存在显著交互作用，但语言记忆、海马体积或皮质淀粉样蛋白负担没有这种作用。具体来说，女性 APOE4 携带者的脑葡萄糖代谢明显高于女性 APOE4 非携带者，而男性 APOE4 携带者的脑葡萄糖代谢低于男性 APOE4 非携带者。总之，在 SMC 患者中，APOE4 对脑葡萄糖代谢的影响受到性别的影响。
