Department of Immunology, Zhuhai Campus of Zunyi Medical University, Zhuhai, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, China.
Department of Physiology, Zhuhai Campus of Zunyi Medical University, Zhuhai, China.
Cytokine. 2020 May;129:155022. doi: 10.1016/j.cyto.2020.155022. Epub 2020 Feb 7.
Previous studies suggest that upregulated basic fibroblast growth factor (bFGF) plays a key role in the resistance to anti-vascular endothelial growth factor (VEGF) therapy in glioma. This study reported that anti-VEGF treatment regulated bFGF secretion in a double-edged manner. That is, moderate VEGF neutralization reduced bFGF production, whereas VEGF overblocking enhanced bFGF secretion in glioma cells. Our data provide a new perspective on the treatment of glioma with anti-VEGF, and the underlying mechanism is worthy of further study.
先前的研究表明，上调的碱性成纤维细胞生长因子（bFGF）在脑胶质瘤对抗血管内皮生长因子（VEGF）治疗的耐药性中起着关键作用。本研究报道抗 VEGF 治疗以一种双刃剑的方式调节 bFGF 的分泌。也就是说，适度的 VEGF 中和减少了 bFGF 的产生，而 VEGF 过度阻断则增强了脑胶质瘤细胞中 bFGF 的分泌。我们的数据为抗 VEGF 治疗脑胶质瘤提供了一个新的视角，其潜在机制值得进一步研究。
