The relation of common inflammatory cytokines with anxiety and depression and their values in estimating cardiovascular outcomes in coronary heart disease patients.

BACKGROUND

Inflammatory cytokines are associated with the occurrence and severity of psychological disorders in cerebro-cardiovascular disease patients. This study aimed to investigate the correlation of inflammatory cytokines with anxiety and depression in coronary heart disease (CHD) patients and their values for estimating cardiovascular outcomes.

METHODS

Totally, 150 CHD patients and 50 healthy subjects were enrolled. Then, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10, and IL-17 in their serum samples were detected using ELISA assay; anxiety and depression were assessed by the HADS score. For CHD patients, major adverse cardiac events (MACE) were recorded and evaluated.

RESULTS

CHD patients presented with increased TNF-α (median: 50.0 vs. 37.0 pg/ml, p < 0.001), IL-1β (median: 2.7 vs. 2.0 pg/ml, p < 0.001), IL-6 (median: 24.7 vs. 24.3 pg/ml, p = 0.032), IL-17A (median: 58.6 vs. 43.6 pg/ml, p < 0.001), HADS-A score (p < 0.001), HADS-D score (p < 0.001), anxiety rate (p < 0.001), and depression rate (p < 0.001) compared to healthy subjects. Then, TNF-α (p = 0.003), IL-1β (p = 0.023), and IL-17A (p < 0.001) were related to elevated HADS-A score. Also, TNF-α (p = 0.014) and IL-17A (p = 0.020) positively, while IL-10 (p = 0.047) negatively related to the HADS-D score in CHD patients. Interestingly, elevated TNF-α and IL-17A were associated with anxiety and depression occurrence in CHD patients (all p < 0.05). Inspiringly, only TNF-α high, but not other cytokines, was related to elevated accumulating MACE (p = 0.041), while no correlation of anxiety (p = 0.173) or depression (p = 0.068) with accumulating MACE was observed.

CONCLUSION

TNF-α and IL-17A correlate with anxiety and depression, while only TNF-α high is related to elevated accumulating MACE in CHD patients.