McHugh W D
Eastman Dental Center, Rochester, NY 14620.
J Periodontol. 1988 Nov;59(11):750-7. doi: 10.1902/jop.1988.59.11.750.
Epithelium was excluded experimentally from artificially induced periodontal pockets by cutting off the crowns of vital teeth and covering the roots with mucoperiosteal flaps. This procedure was carried out on 58 teeth in eight rhesus monkeys and specimens recovered at from five to 36 weeks postoperatively. Thirty-eight (66%) of the teeth remained completely covered by soft tissue for the duration of the experiment. Up to 4.4 mm (mean = 0.9 mm) of new attachment with cementum and attached collagen fibers was found on both the sides of the roots and the cut ends, but root resorption and downgrowth of epithelium over root surfaces were about equally common. Thus, even when epithelium is excluded from healing periodontal pockets, reattachment with new cementum and attached collagen fibers is not consistently achieved, even after periods of 36 weeks. Root resorption and ankylosis are major complications. Although most new attachment appears to result from cells originating in the periodontal ligament, it can also arise from cells from the gingival connective tissue.
通过切除活牙的牙冠并用粘骨膜瓣覆盖牙根，实验性地将上皮组织从人工诱导的牙周袋中排除。对8只恒河猴的58颗牙齿进行了该操作，并在术后5至36周回收标本。在实验期间，38颗（66%）牙齿完全被软组织覆盖。在牙根两侧和切割端发现了高达4.4毫米（平均=0.9毫米）的与牙骨质和附着胶原纤维的新附着，但牙根吸收和上皮在牙根表面的向下生长同样常见。因此，即使上皮组织被排除在愈合的牙周袋之外，即使经过36周，也不能始终实现与新牙骨质和附着胶原纤维的重新附着。牙根吸收和骨粘连是主要并发症。虽然大多数新附着似乎源于牙周膜中的细胞，但也可能源于牙龈结缔组织中的细胞。
