Barranco Rosario, Ventura Francesco
Department of Legal and Forensic Medicine, University of Genova, Via De Toni 12, Genova, 16132, Italy.
Appl Immunohistochem Mol Morphol. 2020 Feb;28(2):95-102. doi: 10.1097/PAI.0000000000000688.
The postmortem diagnosis of acute myocardial infarction is one of the main problems in forensic practice, especially in cases in which death occurs soon after (from minutes to a few hours) the onset of the ischemic damage. Several authors have highlighted the possibility to overcome the limits of conventional histology in this diagnosis by utilizing immunohistochemistry. In the present research, we examined over 30 scientific studies and picked out over 20 main immunohistochemical antigens analyzed with a view to enabling the rapid diagnosis of early myocardial infarction. The aim of our review was to examine and summarize all the principal markers studied to date and also to consider their limitations, including protein alteration because of cadaveric autolysis and putrefaction.
急性心肌梗死的尸检诊断是法医学实践中的主要问题之一，尤其是在缺血性损伤发作后不久（从几分钟到几小时）就发生死亡的案例中。几位作者强调了利用免疫组织化学克服传统组织学在该诊断中局限性的可能性。在本研究中，我们查阅了30多项科学研究，并挑选出20多种主要的免疫组化抗原进行分析，以期实现早期心肌梗死的快速诊断。我们综述的目的是检查和总结迄今为止研究的所有主要标志物，并考虑它们的局限性，包括尸体自溶和腐败导致的蛋白质改变。
