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心肌缺血/再灌注损伤中的膜攻击复合物：用于尸检应用的系统评价

Membrane Attack Complex in Myocardial Ischemia/Reperfusion Injury: A Systematic Review for Post Mortem Applications.

作者信息

Mondello Cristina, Ventura Spagnolo Elvira, Cardia Luigi, Sapienza Daniela, Scurria Serena, Gualniera Patrizia, Asmundo Alessio

机构信息

Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, via Consolare Valeria 1, 98125 Messina, Italy.

Section Legal Medicine, Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Via del Vespro 129, 90127 Palermo, Italy.

出版信息

Diagnostics (Basel). 2020 Nov 2;10(11):898. doi: 10.3390/diagnostics10110898.

DOI:10.3390/diagnostics10110898
PMID:33147886
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7692679/
Abstract

The complement system has a significant role in myocardial ischemia/reperfusion injury, being responsible for cell lysis and amplification of inflammatory response. In this context, several studies highlight that terminal complement complex C5b-9, also known as the membrane attack complex (MAC), is a significant contributor. The MAC functions were studied by many researchers analyzing the characteristics of its activation in myocardial infarction. Here, a systematic literature review was reported to evaluate the principal features, advantages, and limits (regarding the application) of complement components and MAC in post mortem settings to perform the diagnosis of myocardial ischemia/infarction. The review was performed according to specific inclusion and exclusion criteria, and a total of 26 studies were identified. Several methods studied MAC, and each study contributes to defining better how and when it affects the myocardial damage in ischemic/reperfusion injury. The articles were discussed, focusing on the specificity, sensibility, and post mortem stability of MAC as a marker of myocardial ischemia/infarction, supporting the usefulness in routine post mortem investigations.

摘要

补体系统在心肌缺血/再灌注损伤中起重要作用，负责细胞溶解和炎症反应的放大。在此背景下，多项研究强调末端补体复合物C5b-9，也称为膜攻击复合物（MAC），是一个重要因素。许多研究人员通过分析其在心肌梗死中的激活特征来研究MAC的功能。在此，报告了一项系统的文献综述，以评估补体成分和MAC在尸检环境中用于诊断心肌缺血/梗死的主要特征、优点和局限性（关于应用）。该综述根据特定的纳入和排除标准进行，共鉴定出了26项研究。有几种方法研究了MAC，每项研究都有助于更好地确定它如何以及何时影响缺血/再灌注损伤中的心肌损伤。对这些文章进行了讨论，重点关注MAC作为心肌缺血/梗死标志物的特异性、敏感性和尸检稳定性，支持其在常规尸检调查中的有用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edeb/7692679/4e559b19083d/diagnostics-10-00898-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edeb/7692679/a119040d0752/diagnostics-10-00898-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edeb/7692679/fbd3aa5a7000/diagnostics-10-00898-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edeb/7692679/4e559b19083d/diagnostics-10-00898-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edeb/7692679/a119040d0752/diagnostics-10-00898-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edeb/7692679/fbd3aa5a7000/diagnostics-10-00898-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edeb/7692679/4e559b19083d/diagnostics-10-00898-g003.jpg

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