Plesa Adriana, Socolov Demetra, Huica Irina, Botezatu Anca, Iancu Iulia Virginia, Ungureanu Carmen, Teleman Sergiu, Albulescu Adrian, Fudulu Alina, Anton Gabriela
Molecular Virology Department, Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
Department of Obstetrics and Gynecology, Grigore T. Popa University of Medicine and Pharmacy, Iassy, Romania.
J Infect Dev Ctries. 2019 Apr 30;13(4):326-333. doi: 10.3855/jidc.11103.
Romania has the highest incidence and mortality rate of cervical cancer in Europe. The objective was to estimate the prevalence of high-risk human papillomavirus (hrHPV) genotypes and to evaluate the role of certain socio-behavioral factors in acquiring viral infection, in a cohort of Romanian women with negative Pap.
In a prevalence study 611 women (aged 17-58 years) with negative Pap, with no known history of atypical cytology and valid HPV test were included. Each participant completed a questionnaire containing data on socio-behavioral factors. From 344 women aged between 30-58 years, 63 were randomly selected for a second examination (conventional cytology and HPV detection and genotyping) after twelve months.
Of the 611 women, 19.80% were HPV positive, 14.73% infected with hrHPV. Differences in the prevalence of hrHPV (17.60% versus 12.50%) as single (13.01% vs 9.01%) and multiple infections (9.71% vs 3.49%) were noted between women under the age of 30 and above. Among socio-behavioral factors, marital status and multiple sexual partners correlate with HPV and hrHPV infection. At follow-up, from 34 HPV negative cases, 10 changed to positive (5 hrHPV), while 2 developed abnormal cytology. Out of the 29 HPV positive cases, 12 cleared the HPV infection and 17 retested positive of which 4 worsened their cytology.
In Romania, HPV infection is common in women with negative cytology. HPV genotyping is of epidemiological importance because the distribution of hrHPV types can determine the impact of prophylactic vaccines and the necessity of HPV testing as screening method.
罗马尼亚是欧洲宫颈癌发病率和死亡率最高的国家。目的是估计高危型人乳头瘤病毒（hrHPV）基因型的流行率，并评估某些社会行为因素在罗马尼亚巴氏涂片检查结果为阴性的女性群体中获得病毒感染方面的作用。
在一项患病率研究中，纳入了611名巴氏涂片检查结果为阴性、无已知非典型细胞学病史且HPV检测有效的女性（年龄在17 - 58岁之间）。每位参与者完成了一份包含社会行为因素数据的问卷。在344名年龄在30 - 58岁之间的女性中，随机选择63名在12个月后进行第二次检查（传统细胞学检查以及HPV检测和基因分型）。
在611名女性中，19.80%的人HPV呈阳性，14.73%感染了hrHPV。30岁以下和30岁以上女性之间，hrHPV作为单一感染（13.01%对9.01%）和多重感染（9.71%对3.49%）的患病率存在差异（分别为17.60%对12.50%）。在社会行为因素中，婚姻状况和多个性伴侣与HPV和hrHPV感染相关。在随访中，34例HPV阴性病例中有10例转为阳性（5例为hrHPV），同时有2例出现细胞学异常。在29例HPV阳性病例中，12例清除了HPV感染，17例再次检测为阳性，其中4例细胞学结果恶化。
在罗马尼亚，细胞学检查结果为阴性的女性中HPV感染很常见。HPV基因分型具有流行病学意义，因为hrHPV类型的分布可以确定预防性疫苗的影响以及HPV检测作为筛查方法的必要性。
