Departamento Biología Celular, Biología Funcional y Antropología Física, Universitat de València, Calle Dr. Moliner 50, 46100 Burjassot, Spain; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Departamento Biología Celular, Biología Funcional y Antropología Física, Universitat de València, Calle Dr. Moliner 50, 46100 Burjassot, Spain; Instituto de Investigación Sanitaria (INCLIVA), Avenida de Menéndez y Pelayo 4, 46010, Valencia, Spain.
Exp Gerontol. 2020 May;133:110870. doi: 10.1016/j.exger.2020.110870. Epub 2020 Feb 8.
Somatic cells can be reprogrammed to pluripotency by either ectopic expression of defined factors or exposure to chemical cocktails. During reprogramming, somatic cells undergo dramatic changes in a wide range of cellular processes, such as metabolism, mitochondrial morphology and function, cell signaling pathways or immortalization. Regulation of these processes during cell reprograming lead to the acquisition of a pluripotent state, which enables indefinite propagation by symmetrical self-renewal without losing the ability of reprogrammed cells to differentiate into all cell types of the adult. In this review, recent data from different laboratories showing how these processes are controlled during the phenotypic transformation of a somatic cell into a pluripotent stem cell will be discussed.
体细胞可以通过异位表达特定因子或暴露于化学鸡尾酒来重编程为多能性。在重编程过程中，体细胞经历了广泛的细胞过程的剧烈变化，如代谢、线粒体形态和功能、细胞信号通路或永生化。这些过程的调控导致获得多能状态，从而通过对称自我更新实现无限增殖，而不会丧失重编程细胞分化为成体细胞的所有类型的能力。在这篇综述中，将讨论来自不同实验室的最新数据，这些数据显示了在体细胞向多能干细胞的表型转化过程中，这些过程是如何被调控的。
