乳腺癌骨转移：从上皮到间充质转化为乳腺癌成骨样细胞。

Breast cancer metastasis to bone: From epithelial to mesenchymal transition to breast osteoblast-like cells.

机构信息

Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, Rome, 00133, Italy; San Raffaele University, Via di Val Cannuta 247, 00166, Rome, Italy; Fondazione Umberto Veronesi (FUV), Piazza Velasca 5, 20122, Milano, Mi, Italy; Saint Camillus International University of Health Sciences, Via di Sant'Alessandro, 8, 00131 Rome, Italy.

Department of Experimental Medicine, University "Tor Vergata", Via Montpellier 1, Rome, 00133, Italy.

出版信息

Semin Cancer Biol. 2021 Jul;72:155-164. doi: 10.1016/j.semcancer.2020.01.004. Epub 2020 Feb 8.

DOI:10.1016/j.semcancer.2020.01.004

PMID:32045651

Abstract

In this review we highlighted the newest aspects concerning the physiopathology of breast cancer metastatization into the bone including: a) in situ biomarkers of breast cancer metastatic diseases, b) biological processes related to the origin of metastatic cells (epithelial to mesenchymal transition), c) the nature and the possible role of Breast Osteoblast-Like Cells in the formation of bone lesions and d) the prognostic value of breast microcalcifications for the bone metastatic disease. In addition, the more recent data about the biology of breast cancer metastatic process and the origin and function of Breast Osteoblast-Like Cells have been analyzed to propose the use of molecular imaging investigations able to identify early neoplastic lesions with high propensity to form bone metastasis in vivo.

摘要

在这篇综述中，我们强调了乳腺癌转移到骨骼的病理生理学的最新方面，包括：a）乳腺癌转移疾病的原位生物标志物，b）与转移细胞起源相关的生物学过程（上皮间质转化），c）乳腺癌成骨样细胞在骨损伤形成中的性质和可能作用，以及 d）乳腺微钙化对骨转移疾病的预后价值。此外，还分析了关于乳腺癌转移过程的生物学以及乳腺癌成骨样细胞的起源和功能的最新数据，以提出使用分子成像研究来识别具有体内形成骨转移高倾向的早期肿瘤病变。