State Key Laboratory of Natural Medicines & Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, People's Republic of China.
State Key Laboratory of Natural Medicines & Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, People's Republic of China.
Fitoterapia. 2020 Jul;144:104494. doi: 10.1016/j.fitote.2020.104494. Epub 2020 Feb 8.
Two new phthalideisoquinoline hemiacetal alkaloid derivatives, named corybensines A and B (1 and 2), and four known alkaloids (3-6) were isolated from the bulbs of Corydalis decumbens. Their structures were characterized by analysis of 1D/2D NMR and ECD data, quantum chemical ECD calculations, and X-ray diffraction analysis. Among them, compound 2 represents the first naturally occurring phthalideisoquinoline hemiacetal alkaloid derivative with a 2-pyrrolidinone moiety. The activity of the isolated compounds towards neuronal excitability was examined.
从延胡索属植物中分离得到两个新的苯酞异喹啉半缩醛生物碱衍生物，命名为科布嗪 A 和 B（1 和 2），以及四个已知的生物碱（3-6）。它们的结构通过 1D/2D NMR 和 ECD 数据分析、量子化学 ECD 计算和 X 射线衍射分析进行了表征。其中，化合物 2 代表了第一个具有 2-吡咯烷酮部分的天然苯酞异喹啉半缩醛生物碱衍生物。对分离得到的化合物对神经元兴奋性的活性进行了研究。
