社交从众对 Wistar 大鼠乙醇偏好的影响。
Impact of Social Conformity on Ethanol Preference in Wistar Rats.
机构信息
Laboratory of Behavioral Neuroscience and Pathology, Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, Saint Petersburg, Russian Federation.
Laboratory of Behavioral Neuroscience and Pathology, Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, Saint Petersburg, Russian Federation,
出版信息
Eur Addict Res. 2020;26(2):96-102. doi: 10.1159/000506157. Epub 2020 Feb 11.
INTRODUCTION
Social conformity is considered a possible promoter of alcohol use disorder in humans. The goal of this study was to explore the impact of conformity as one of the social factors that might contribute to the alcohol preference in a rat model of ethanol intake.
METHODS
To model social conformity, 105 Wistar rats were group housed (3 animals per cage) with a different number of rats drinking either 10% ethanol or water during daily drinking sessions. Ethanol preference tests were performed.
RESULTS
Ethanol preference significantly increased if the majority of cage mates received ethanol during drinking sessions. The analysis also showed an increase in the number of approaches to the ethanol bottle versus the water bottle and an increased duration of a single ethanol approach during the 2 bottle preference test in such groups.
CONCLUSION
These results demonstrate that social conditions promote the ethanol consumption in the novel conformity model used in this study.
简介
社会从众被认为是人类酗酒障碍的一个可能促进因素。本研究的目的是探讨从众作为可能导致酒精偏好的社会因素之一，对摄入乙醇的大鼠模型的影响。
方法
为了模拟社会从众，105 只 Wistar 大鼠被分组饲养（每笼 3 只），每天的饮酒时间内，一组的大鼠饮用 10%乙醇，另一组的大鼠饮用清水。进行乙醇偏好测试。
结果
如果大多数笼内同伴在饮酒期间接受乙醇，那么乙醇偏好就会显著增加。分析还显示，在这种情况下，与水相比，对乙醇瓶的接近次数增加，在双瓶偏好测试中，单次接近乙醇的持续时间增加。
结论
这些结果表明，在本研究中使用的新的从众模型中，社会条件促进了乙醇的摄入。
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