Simkin P A
Department of Medicine, University of Washington, Seattle 98195.
J Rheumatol Suppl. 1988 Oct;17:40-3.
For the most part, plasma concentrations of nonsteroidal antiinflammatory drugs (NSAID) have not correlated well with assessments of therapeutic response. This disappointing record may largely reflect weaknesses in experimental design. It may also be, however, that concentrations in plasma bear only a distant relationship to those in the inflamed tissues where NSAID presumably act. Elimination kinetics, protein binding, fat solubility, tissue blood flow, and uptake by cells may be determinants of concentration and response in target tissues. These factors are considered as they relate to NSAID concentrations in synovial effusions.
在很大程度上，非甾体抗炎药（NSAID）的血浆浓度与治疗反应评估之间的相关性并不好。这一令人失望的结果可能在很大程度上反映了实验设计的缺陷。然而，也有可能血浆浓度与NSAID可能发挥作用的炎症组织中的浓度仅有微弱的关系。消除动力学、蛋白结合、脂溶性、组织血流量以及细胞摄取可能是靶组织中浓度和反应的决定因素。本文将讨论这些因素与滑膜液中NSAID浓度的关系。
