Inutsuka S, Kumashiro R, Maekawa T, Hirabayashi M, Naitoh H, Kamachi H
Second Department of Surgery, School of Medicine, Fukuoka University.
Jpn J Clin Oncol. 1988 Dec;18(4):357-62.
The serum testosterone level (STL) was determined in 181 patients with gastric carcinoma, 128 male and 53 female, and in 98 patients with benign diseases, 67 male and 31 female. As in our previous report, the preoperative STL of the cancer group was significantly lower than that of the control group, in both male and female patients (P less than 0.001). In the present study, the STL of the perigastric vein draining the stomach was determined and compared with the STL of the blood obtained at the same time from the peripheral vein during the operation. It was found that, in the male patients, the STL of the blood obtained from the perigastric vein draining a stomach with carcinoma was significantly lower than that of the peripheral vein in the same patient (P less than 0.001); however, there was no difference between these STL in the control group. On the contrary, in the female patients during operation, no such phenomenon was confirmed. Analysis classifying the patients by histological type revealed almost the same results for all patients as those shown for the cancer group, i.e. there was a proven significant difference in male patients and no significant difference in female patients. It was therefore considered that the mechanism of decrease in preoperative peripheral STL was not always the same in male patients as in female patients, although the STL decrease was observed to be similar in both sexes before surgery.
对181例胃癌患者（男性128例，女性53例）以及98例良性疾病患者（男性67例，女性31例）测定了血清睾酮水平（STL）。正如我们之前的报告所示，无论男性还是女性患者，癌症组术前的STL均显著低于对照组（P<0.001）。在本研究中，测定了引流胃的胃周静脉的STL，并与手术期间同时从外周静脉采集的血液的STL进行比较。结果发现，在男性患者中，从患有癌症的胃引流的胃周静脉采集的血液的STL显著低于同一患者外周静脉的STL（P<0.001）；然而，对照组中这些STL之间没有差异。相反，在女性患者手术期间，未证实有此类现象。按组织学类型对患者进行分类分析显示，所有患者的结果与癌症组几乎相同，即男性患者有显著差异，女性患者无显著差异。因此，尽管术前观察到两性的STL下降情况相似，但认为男性患者术前外周STL下降的机制与女性患者并不总是相同。
