Aikawa H, Momotani H, Shigeta S
Department of Environmental Medicine and Occupational Health, School of Medicine, Tokai University.
Sangyo Igaku. 1988 Sep;30(5):379-84. doi: 10.1539/joh1959.30.379.
The present experiment was conducted under the assumption that exposure conditions (time of exposure, concentration of exposed substances and working intensity) should be taken into account in estimating the level of invasion of injurious substances into the human body. Experiments were carried out on rats under various exposure conditions of toluene and the toluene concentration in the blood was monitored for the estimation of its intake. The results were as follows; 1. It was confirmed that toluene concentration in blood increased and plateau-time was delayed in proportion to increase in exposure concentration. 2. Light exercise (5.0, 7.0 m/min) increased toluene concentration in blood and it was proportioned to intensity of physical exercise. 3. Light daily exercise (2.7 m/min) for six days increased toluene concentration in blood gradually day after day when compared to exposure without exercise, though the exposure conditions were the same every day. It is thus considered that physical exercise is one of the very important factors in estimation of exposure.
在估计有害物质侵入人体的程度时，应考虑暴露条件（暴露时间、暴露物质浓度和工作强度）。在不同的甲苯暴露条件下对大鼠进行实验，并监测血液中的甲苯浓度以估计其摄入量。结果如下：1. 证实血液中的甲苯浓度随着暴露浓度的增加而升高，且达到平稳期的时间延迟。2. 轻度运动（5.0、7.0米/分钟）会使血液中的甲苯浓度升高，且与体育锻炼强度成正比。3. 与无运动的暴露情况相比，在相同的每日暴露条件下，连续六天进行轻度日常运动（2.7米/分钟）会使血液中的甲苯浓度逐日逐渐升高。因此，可以认为体育锻炼是估计暴露情况的非常重要的因素之一。
