Wei Shuguang, Zou Zilan, Xue Zhaoxia, Cao Siqi, Yu Hao, Han Jie, Wang Haiyan, Wu Haiyan, Liu Xun
Department of Psychology, Faculty of Education, Henan Normal University, Xinxiang, China.
Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Front Psychol. 2020 Jan 28;11:88. doi: 10.3389/fpsyg.2020.00088. eCollection 2020.
Individuals with methamphetamine use disorder are considered to have enhanced reactivity to rewards or drug cues. However, whether this holds true in the social incentives processing is still unclear. The current study investigated the electroencephalographical (EEG) evidence of social incentives processing in women with methamphetamine use disorder (MA group, = 19) and in a healthy control group (HC group, = 20) using social incentive delay (SID) tasks. In the SID, participants received a "Like" (e.g., thumbs up) or "Unlike" (e.g., thumbs down) from WeChat emojis as social incentives, or neutral feedback. During the anticipation stage, the Cue-P3 and stimulus-preceding negativity (SPN) were larger for the social incentives condition than for the neutral condition. During the consummation stage, the feedback-related negativity (FRN) was marginally significantly larger in the HC group than the MA group for the social incentive condition, whereas there was no significant difference between the groups for neutral condition. Interestingly, the FB-P3 was larger for social positive feedback than for social negative feedback in the MA group, but not in HC group. Furthermore, only the HC group showed significant positive correlation between the anticipatory event-related brain potential (ERP, such as Cue-P3) and the consummatory ERP (FB-P3) in the social incentive condition. The findings suggest that women with MA use disorder have a blunted neural response to the processing of social incentives and a blunted neural response to negative social feedback, which helps to elucidate the neural mechanisms of social incentives processing in individuals with MA use disorder.
患有甲基苯丙胺使用障碍的个体被认为对奖励或药物线索具有增强的反应性。然而，在社会奖励处理方面是否如此仍不清楚。当前研究使用社会奖励延迟（SID）任务，调查了患有甲基苯丙胺使用障碍的女性（MA组，n = 19）和健康对照组（HC组，n = 20）在社会奖励处理方面的脑电图（EEG）证据。在SID任务中，参与者收到来自微信表情符号的“点赞”（如竖起大拇指）或“不喜欢”（如大拇指向下）作为社会奖励，或中性反馈。在预期阶段，社会奖励条件下的线索P3和刺激前负波（SPN）比中性条件下更大。在消费阶段，对于社会奖励条件，HC组的反馈相关负波（FRN）略显著大于MA组，而在中性条件下两组之间没有显著差异。有趣的是，在MA组中，社会积极反馈的FB-P3比社会消极反馈的更大，但在HC组中并非如此。此外，只有HC组在社会奖励条件下的预期事件相关脑电位（ERP，如线索P3）和消费ERP（FB-P3）之间显示出显著的正相关。研究结果表明，患有甲基苯丙胺使用障碍的女性对社会奖励处理的神经反应迟钝，对负面社会反馈的神经反应也迟钝，这有助于阐明患有甲基苯丙胺使用障碍个体的社会奖励处理的神经机制。
