Wei Shuguang, Zheng Ya, Li Qi, Dai Weine, Sun Jinxiu, Wu Haiyan, Liu Xun
College of Education, Henan Normal University, Xinxiang, China; CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China.
Department of Psychology, Dalian Medical University, Dalian, China.
Physiol Behav. 2018 Oct 15;195:118-127. doi: 10.1016/j.physbeh.2018.08.003. Epub 2018 Aug 11.
Converging evidence supports that addiction involves the pathological usurpation of normal reward processes. However, the nature and direction of reward processing dysfunction in substance abusers remain unclear. The current study explored the electrophysiological responses associated with different stages of reward processing in methamphetamine (MA) use disordered individuals. Electroencephalography recording was used to compare responses of 21 MA use disordered individuals and 22 healthy controls (HC) while participants engaged in a simple gambling task. Compared to HC, MA use disordered individuals made more risky choices following a loss outcome on a previous trial. During the reward anticipatory stage, MA use disordered individuals showed an enhanced stimulus-preceding negativity (SPN), as compared to HC. During the reward outcome stage, MA use disordered individuals showed an enhanced feedback-related negativity (FRN) for the losses versus gains as compared to HC. Furthermore, an enhanced P300 was observed under the gain condition, but not under the loss condition, in MA use disordered individuals as compared to HC. These findings provide further evidence that MA use disordered individuals have a sensitized neural response to non-drug rewards and support the impulsivity and incentive sensitization theories in MA use disordered individuals. The current study helps to elucidate the neural mechanisms of reward processing in MA use disordered individuals.
越来越多的证据支持成瘾涉及对正常奖励过程的病理性篡夺。然而，药物滥用者奖励处理功能障碍的性质和方向仍不清楚。当前的研究探讨了与甲基苯丙胺（MA）使用障碍个体奖励处理不同阶段相关的电生理反应。在参与者进行简单赌博任务时，使用脑电图记录来比较21名MA使用障碍个体和22名健康对照者（HC）的反应。与HC相比，MA使用障碍个体在前一次试验出现损失结果后会做出更多冒险选择。在奖励预期阶段，与HC相比，MA使用障碍个体表现出增强的刺激前负波（SPN）。在奖励结果阶段，与HC相比，MA使用障碍个体对损失与收益表现出增强的反馈相关负波（FRN）。此外，与HC相比，MA使用障碍个体在获得条件下观察到P300增强，但在损失条件下未观察到。这些发现提供了进一步的证据，表明MA使用障碍个体对非药物奖励有敏感的神经反应，并支持MA使用障碍个体的冲动性和奖励敏感化理论。当前的研究有助于阐明MA使用障碍个体奖励处理的神经机制。
