Department of Neurological Surgery and The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, United States.
Center for Cognitive Neuroscience and Aging, University of Miami Miller School of Medicine, Miami, FL, United States.
Front Endocrinol (Lausanne). 2020 Jan 28;11:8. doi: 10.3389/fendo.2020.00008. eCollection 2020.
The inflammasome is a key regulator of innate immunity involved in the inflammatory response to infections as well as disease through the activation of caspase-1 and the processing of the inflammatory cytokines interleukin (IL)-1β and IL-18. Even though the inflammasome was first described in the context of infections, most research in recent years has focused on targeting the inflammasome as a therapeutic option in sterile inflammatory events. Recent evidence indicates a clear involvement of the inflammasome in Reproductive Biology such as infertility and preeclampsia. In this mini-review, I summarize the current findings on the inflammasome that have been described in the field of Reproductive Biology and highlight the potential that the inflammasome has as a novel therapeutic option in this field. The topics covered in this review as it pertains to the inflammasome field cover the literature published on male and female infertility, endometriosis, preeclampsia, placental inflammation, and reproductive senescence.
炎症小体是先天免疫的关键调节剂，通过半胱天冬酶-1 的激活和炎性细胞因子白细胞介素（IL）-1β和 IL-18 的加工，参与对感染以及疾病的炎症反应。尽管炎症小体最初是在感染的背景下描述的，但近年来的大多数研究都集中在将炎症小体作为无菌性炎症事件的治疗选择。最近的证据表明，炎症小体在生殖生物学如不孕和子痫前期中明显参与。在这篇迷你综述中，我总结了炎症小体在生殖生物学领域的最新发现，并强调了炎症小体作为该领域新的治疗选择的潜力。本综述中涉及炎症小体领域的主题包括关于男性和女性不孕、子宫内膜异位症、子痫前期、胎盘炎症和生殖衰老的文献。
