磷酸酶和张力蛋白同源物（PTEN）、雌激素受体（ER）和孕激素受体（PR）的三高表达可能预示着I型子宫内膜癌患者的预后良好。

Triple-high expression of phosphatase and tensin homolog (PTEN), estrogen receptor (ER) and progesterone receptor (PR) may predict favorable prognosis for patients with Type I endometrial carcinoma.

作者信息

Liang Yanfang, Lin Bihua, Ye Ziyu, Chen Shasha, Yu Haibo, Chen Can, Zhang Xin, Zhou Keyuan, Zeng Jincheng

机构信息

Department of Pathology, Dongguan Hospital Affiliated to Medical College of Jinan University, The Fifth People's Hospital of Dongguan, Dongguan 523905, China.

Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, Guangdong 523808, China.

出版信息

J Cancer. 2020 Jan 13;11(6):1436-1445. doi: 10.7150/jca.33720. eCollection 2020.

DOI:10.7150/jca.33720

PMID:32047550

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6995374/

Abstract

Endometrial carcinoma (EC) is the most common malignant tumors in female derived from the endometrial epithelium. Several previous studies have described estrogen receptors (ER), progesterone Receptor (PR) and phosphatase and tensin homolog (PTEN) are associated with clinicopathological factors and prognosis in EC patients. However, during EC patients follow-up, we found that some EC patients with down-regulation of PTEN, but up-regulation of ER or PR , and some EC patients with down-regulation of ER or PR, but up-regulation of PTEN also had a poor prognosis. Therefore, to reveal the prognosis of EC patients with different phenotypes based on PTEN, ER and PR expression, 120 cases formalin-fixed paraffin-embedded EC tissues and 543 cases uterine corpus endometrial carcinoma (UCEC) patients from the cancer genome atlas (TCGA) UCEC datasets were analyzed. Results showed that EC tissues can be classified to PTENERPR, PTENERPR, PTENERPR, PTENERPR, PTENERPR, PTENERPR, and PTENERPR phenotypes basing on IHC analysis. Additionally, EC patients with PTENERPR showed high malignancy, while patients with PTENERPR showed low malignancy. Therefore, combined detection of PTEN, ER, PR may help identify a small subset of EC with more aggressive behavior and may aid in risk stratification.

摘要

子宫内膜癌（EC）是女性最常见的源自子宫内膜上皮的恶性肿瘤。此前的多项研究表明，雌激素受体（ER）、孕激素受体（PR）和磷酸酶及张力蛋白同源物（PTEN）与EC患者的临床病理因素及预后相关。然而，在对EC患者的随访过程中，我们发现一些PTEN下调但ER或PR上调的EC患者，以及一些ER或PR下调但PTEN上调的EC患者预后也较差。因此，为了揭示基于PTEN、ER和PR表达的不同表型EC患者的预后情况，我们分析了120例福尔马林固定石蜡包埋的EC组织以及来自癌症基因组图谱（TCGA）子宫体子宫内膜癌（UCEC）数据集的543例UCEC患者。结果显示，基于免疫组化分析，EC组织可分为PTENERPR、PTENERPR、PTENERPR、PTENERPR、PTENERPR、PTENERPR和PTENERPR表型。此外，PTENERPR的EC患者显示出高恶性，而PTENERPR的患者显示出低恶性。因此，联合检测PTEN、ER、PR可能有助于识别一小部分具有更侵袭性行为的EC患者，并有助于进行风险分层。