子宫内膜增生症的子宫微生物组改变。
An altered uterine microbiota with endometrial hyperplasia.
机构信息
Department of Ambulatory Surgery, Women's Hospital, Zhejiang University School of Medicine, China. 1 Xueshi Road, Hangzhou, Zhejiang, 310006, P.R. China.
出版信息
BMC Microbiol. 2024 Jul 12;24(1):258. doi: 10.1186/s12866-024-03379-1.
BACKGROUND
Endometrial hyperplasia (EH) is a precursor to endometrial cancer, and the role of the microbiome in its development is unclear.
RESULTS
The present study investigated the uterine microbiome in patients with benign uterine conditions and endometrial hyperplasia. A significant structural shift in the uterine microbiome of patients with endometrial hyperplasia compared to those with benign conditions was found. Delftia, Serratia and Stenotrophomonas were significantly enriched in endometrial hyperplasia samples and associated with the presence of endometrial hyperplasia.
CONCLUSIONS
The novel finding suggested that increased abundance of Delftia, Serratia and Stenotrophomonas is associated with the presence of endometrial hyperplasia. Further investigation is needed to determine the value of these microbes as biomarkers for endometrial hyperplasia.
背景
子宫内膜增生（EH）是子宫内膜癌的前身，微生物组在其发展中的作用尚不清楚。
结果
本研究调查了良性子宫疾病和子宫内膜增生患者的子宫微生物组。与良性疾病患者相比，子宫内膜增生患者的子宫微生物组结构发生了显著变化。Delftia、Serratia 和 Stenotrophomonas 在子宫内膜增生样本中明显富集，并与子宫内膜增生的存在相关。
结论
这一新颖的发现表明，Delftia、Serratia 和 stenotrophomonas 的丰度增加与子宫内膜增生的存在有关。需要进一步研究来确定这些微生物作为子宫内膜增生生物标志物的价值。
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